Gene therapy for the prevention of autoimmune disease

Details Gene therapy for the prevention of autoimmune disease Gene therapy for the prevention of autoimmune disease

2002-10-02

2008-05-27

Ewoldt, G. R (Department: 1644)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

Reexamination Certificate

active

07378089

ABSTRACT:
Autoimmune disease is treated by the delivery of a suppressive agent to the site of disease. Delivery is accomplished by introducing an expression vector encoding the suppressive agent into cells targeted for such sites, and administering the genetically modified cells to the patient. Suppressive agents of particular interest include IL-4; and anti-CD3 antibodies, particularly single chain anti-CD3 antibodies. Cells of interest for delivery include T cells and T cell hybridomas, where the T cell antigen receptor recognizes epitopes associated with the autoimmune disease. Alternatively, dendritic cells are used as delivery vectors.

REFERENCES:
patent: 5958403 (1999-09-01), Strom et al.
patent: 6274136 (2001-08-01), Weiner et al.
Feili-Hariri, M., et al. Diabetes. 1999;48:2300-2308.
Cameron, M.J., et al. Hum. Gene. Ther. 2000;11:1647-1656.
Chen et al., A gene therapy approach for treating T cell mediated autoimmune diseases, (2001), Blood, 97: 886-894.
Yasuda et al., Local expression of immunoregulatory IL-12p40 gene prolonged syngeneic islet graft survival in diabetic NOD mice, (1998), J. Clin. Invest., 102: 1807-1814.
Costa et al., (2001), J. Immunol., 167(4): 2379-2387.
Costa et al., (2000), J. Immunol., 164: 3851-3590.
Gallichan et al., (1998), Hum. Gene Ther., 9(18): 2717-2726.
Issazadeh et al., (1995), J. Neuroimmunol, 61:205-12.
Macatonia et al., (1993), Int. Immunol., 5: 1119-28.
Nakajima et al., (2001), The Journal of Clinical Investigation, 107(10): 1293-1301.
Racke et al., (1994), J. Exp. Med., 180: 1961-6.
Shaw et al., (1997), J. Exp. Med., 185(9): 1711-1714.
Smith et al., (1997), Transplantation, 64(7): 1040-1049.
Takayama et al., (2001), Transplantation, 71: 1334-1340.
Voorthuis et al., (1990), Clin. Exp. Immunol., 81: 183-8.
Yamamoto et al., (2001), J. Immunol., 166: 4973-4980.

Affiliated with

Also associated with

Rating

Gene therapy for the prevention of autoimmune disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gene therapy for the prevention of autoimmune disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene therapy for the prevention of autoimmune disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3987509