Gene therapy for solid tumors, using a DNA sequence encoding HSV

Details Gene therapy for solid tumors, using a DNA sequence encoding HSV Gene therapy for solid tumors, using a DNA sequence encoding HSV

1993-08-26

1997-05-20

Stone, Jacqueline M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 936, 4353201, A61K 4800, A01N 6300, C12N 500

Patent

active

056312369

ABSTRACT:
The present invention provides a novel method of treating localized solid tumors and papilloma in an individual. The method comprises introducing a recombinant adenoviral vector containing the herpes simplex virus-thymidine kinase gene. Subsequently, a prodrug, such as the drug ganciclovir, is administered to the individual. The methods of the present invention may be used to treat several different types of cancers and papillomas, including colon carcinoma, prostate cancer, breast cancer, lung cancer, melanoma, hepatoma, brain and head and neck cancer.

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