Gene therapy for muscular dystrophy

Details Gene therapy for muscular dystrophy Gene therapy for muscular dystrophy

1995-06-07

1999-11-16

Campell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, A01N 4304, C12N 1500

Patent

active

059858460

ABSTRACT:
A gene transfer vector comprising adenovirus inverted terminal repeats, recombinant adenovirus particles containing the same, a method for producing the same and a method of use of the same to introduce and express a foreign gene in eukaryotic cells, and to treat muscular dystrophy, is disclosed.

REFERENCES:
patent: 5670488 (1997-09-01), Gregory et al.
Mitani et al, "Rescue, Propagation, and Partial Purification of a Helper Virus-Dependent Adenovirus Vector", Proc. Natl. Acad. Sci. USA, 92:3854-3858 (1995).
Deuring et al, "An Unusual Symmetric Recombinant Between Adenovirus Type 12 DNA and Human Cell DNA", Proc. Natl. Acad. Sci. USA, 78(5):3142-3146 (1981).
Gilardi et al. Expression of human alpha-1-antitrypsin using a recombinant adenovirus vector. FEBS Letters, vol. 267, No. 1, pp. 60-62, Jul. 1990.
Berkner, K. L. Development of Adenovirus Vectors for the Expression of Heterologous Genes. Biotechniques. vol. 6, No. 7, pp. 616-629, 1988.
Karpati et al., Clin. Invest. Med., 17(5), 1994, 499-509.
Amalfitano et al., Am. J. Human Genetics, 57 (4 supp) 1995, A234.
Marshall, Science, 269, 1995, 1050-1055.
Miller et al., FASEB J., 9, 1995, 190-199.
Culver et al., TIG, 1994, 10(5), 174-178.
Hodgson, Exp. Op. Ther. Pat., 5(5), 1995, 459-468.

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