Gene therapy for alleviating erectile dysfunction

Details Gene therapy for alleviating erectile dysfunction Gene therapy for alleviating erectile dysfunction

1997-02-13

2000-11-21

Elliott, George C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435325, 435366, 536 231, A61K 4800, C12N 1585, C07H 2104

Patent

active

06150338&

ABSTRACT:
The present invention is directed towards gene therapy for erectile dysfunction through delivery and expression of a recombinant vector containing a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a smooth muscle cell. Also provided by the present invention is a method of inducing penile erection in a subject comprising the introduction and expression of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a sufficient number of cells of the subject to induce penile erection in the subject. The present invention also provides a recombinant vector comprising the DNA of or corresponding to at least a portion of the genome of a virus, which portion is capable of directing the expression of a DNA sequence, and DNA encoding a protein involved in the regulation of smooth muscle tone operably linked to the viral DNA and capable of being expressed as a functional gene product in the target cell. Also provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.

REFERENCES:
patent: 5214030 (1993-05-01), Stief
patent: 5219748 (1993-06-01), Yoshitaka et al.
patent: 5324651 (1994-06-01), Ono et al.
patent: 5594032 (1997-01-01), Gonzalez-Cadavid et al.
Christ et al., Molecular studies of human corporal smooth muscle: implications for the understanding, diagnosis, and treatment of erectile dysfunction, Mol. Urol. vol. 1 (1), pp. 45-54, 1997.
Wegner et al., Nitric oxide donor, linsidomine chlorhydrate (SIN-1), in the diagnosis and treatment of erectile dysfunction: critical appraisal and review of the literature, Int. Urol. Nephrol., vol. 27 (5), pp. 621-628, 1995.
George J. Christ, Ph.D., The Penis as a Vascular Organ. The Importance of Corporal Smooth Muscle Tone in the Control of Erection, Urol. Clin. North Am., vol. 22(4), pp 727-745, Nov. 1995.
Lerner, et al., A Review of Erectile Dysfunction: New insights and more questions, The Journal of Urology, vol. 149, pp 1246-1255, May 1993.
Christ, et al., Characterization of K Currents in Cultured Human corporal Smooth Muscle Cells, Journal of Andrology, vol. 14(5), pp. 319-328, Sep./Oct. 1993.
G.J. Christ, The "Syncytial Tissue Triad": A model for understanding how gap junctions participate in the local control of penile erection, World J. of Urology, vol. 15, pp. 36-44, 1997.
Christ, et al., The Role of Gap Junctions and Ion Channels in the Modulation of Electrical and Chemical Signals in Human Corpus Cavernosus Smooth Muscle, Int. J. Impotence Res. (1993) pp 577-96.
Fan, et al., An Analysis of the Maxi-K+(K.sub.Ca) Channel in Cultured Human Corporal Smooth Muscle Cells, The Journal of Urology, vol. 153, pp. 818-825, Mar. 1995.
Nabel, et al., Site-specific gene expression in vivo by direct gene expression into the arterial wall, Science, vol. 249:1285-8 (1990).
McCobb, et al., Human calcium-activated potassium channel gene expressed in vascular smooth muscle, Am. J. Physiol., vol. 269: H767-77 (1995).

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