Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Reexamination Certificate
2007-05-15
2007-05-15
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
C435S440000, C435S461000, C514S04400A, C424S093210
Reexamination Certificate
active
09392682
ABSTRACT:
A method for gene therapy using small fragment homologous replacement. The method introduces small fragments of exogenous DNA into regions of endogenous genomic DNA virtually homologous to the exogenous DNA. The exogenous DNA fragments contains sequence modification that correct mutations in the endogenous DNA or introduce mutations that alter cellular or an infecting pathogen phenotype.
REFERENCES:
patent: 4950599 (1990-08-01), Bertling
patent: 5612205 (1997-03-01), Kay et al.
patent: 5789215 (1998-08-01), Berns et al.
patent: 6010908 (2000-01-01), Gruenert et al.
patent: WO 91/10734 (1991-07-01), None
Verma et al (1997) Nature 389:239-242.
Palu et al (1999) J. Biotechnol. 68: 1-13.
Luo et al (2000) Nature Biotechnology 18:33-37.
Fox, ASM News, Feb. 2000, 66 (2): 1-3.
Vega (1991) Human Genetics 87:245-253.
Shesely et al (1991) Proc. Natl. Acad. Sci. USA 88:4294-4298.
Crystal Science vol. 270 Oct. 20, 1995 404-409.
Eric J. Sorscher et al, Gene Therapy for Cystic Fibrosis Using Cationic Liposome Mediated Gene Transfer: A Phase I Trial of Safety and Efficacy in the Nasal Airway, Human Gene Therapy, 5:1259-1277, Oct. 1994.
James M. Wilson et al, Gene Therapy of Cystic Fibrosis Lung Disease Using E1 Deleted Adenoviruses: A Phase I Trial, Human Gene Therapy, 5:501-519, 1994.
Natasha J. Caplen et al, Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis, Nature Medicine, vol. 1, No. 1, pp. 39-46, Jan. 1995.
Richard M. Boucher et al, Gene Therapy for Cystic Fibrosis Using E1-Deleted Adenovirus: A Phase I Trial in the Nasal Cavity, Human Gene Therapy 5:615-639, 1994.
Mitchell J. Goldman et al, Gene Therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect, Nature Genetics, vol. 9, pp. 126-131 Feb. 1995.
Joe Palca, The Promise of a Cure, Discover, pp. 79-86, Jun. 1994.
Joseph Zabner et al, Adenovirus-Mediated Gene Transfer Transiently Corrects the Chloride Transport Defect in Nasal Epithelia of Patients with Cystic Fibrosis, Cell, vol. 75, pp. 207-216, Oct. 22, 1993.
Terrence R. Flotte et al, An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction, Gene Therapy, 2, pp. 29-37, 1995.
J.A. Dodge, Gene therapy for cystic fibrosis, Nature Medicine, vol. 1, No. 3, pp. 182, Mar. 3, 1995.
Deborah Erickson, Genes to Order, Scientific American, pp. 112-114, Jun. 1992.
James M. Wilson, Vehicles for gene therapy, Nature, vol. 365, pp. 691-692, Oct. 21, 1993.
Eric Alton & Duncan Geddes, A mixed message for cystic fibrosis gene therapy, Nature Genetics, vol. 8, pp. 8-9, Sep. 1994.
James J. Logan et al, Cationic lipids for reporter gene and CFTR transfer to rat pulmonary epithelium, Gene Therapy 2, pp. 38-49, 1995.
Orban, P.C., et al., “Tissue- and Site-Specific DNA Recombination in Transgenic Mice”, P.N.A.S., USA 89:6861-6865 (1992).
Rosenfeld, M.A., et al., “In Vivo Transfer of the Human Cystic Fibrosis Transmembrane Conductance Regulator Gene to the Airway Epithelium”, Cell 68:143-155 (1992).
Capecchi, M.R., “Altering the Genome by Homologous Recombination”, Science 244:1288-1292 (1989).
Boggs, S.S., “Targeted Gene Modification for Gene Therapy of Stem Cells”, International J. of Cell Cloning 8:80-96 (1990).
Thomas, K.M. and Capecchi, M.r., “Targeted Disruption of the Murine int-I Proto-Oncogene Resulting in Severe Abnormalities in Midbrain and Cerebellar Development”, Nature, 346:847-850 (1990).
Koller, B.H., “Inactivating the β2-Microglobulin Locus in Mouse Embryonic Stem Cells by Homologous Recombination”, P.N.A.S. USA 86:8932-8935 (1989).
Mansour, S.L., et al., “Disruption of the Proto-Oncogene int-2 in Mouse Embryo-Derived Stem Cells: a General Strategy for Targeting Mutations to Non-Selectable Genes”, Nature 336:348-352 (1988).
Accili, D. and Taylor, S.I., “Targeted Inactivation of the Insulin Receptor Gene in Mouse 3T3-L1 Fibroblasts Via Homologous Recombination”, P.N.A.S. USA 88:4708-4712 (1991).
Thompson, S., et al., “Germ Line Transmission and Expression of a Corrected HPRT Gene Produced by Gene Targeting in Embryonic Stem Cells”, Cell 56:313-321 (1989).
Koller, B.H., et al., “Germ-Line Transmission of a Planned Alteration Made in a Hypoxanthine Phosphoribosyltransferase Gene by Homologous Recombination in Embryonic Stem Cells”, P.N.A.S. USA 86:8927-8931 (1989).
Adair, G.A., et al., “Targeted Homologous Recombination at the Endogenous Adenine Phophoribosyltransferase Locus in Chinese Hamster Cells”, P.N.A.S USA 86:4574-4578 (1989).
Kucheriapati, R.S., et al., “Homologous Recombination Catalyzed by Human Cell Extracts”, Mol. and Cell. Biol. vol. 5 4:714-720 (1985).
Campbell, C.R., et al., “Homologous Recombination Involving Small Single-Stranded Oligonucleotide in Human Cells”, The New Biologist vol. 1 2:223-227 (1989).
Lin, F., et al., “Model for Homologous Recombination During Transfer of DNA into Mouse L. Cells: Role for DNA Ends in the Recombination Process”, Mol. and Cell. Biol. vol. 4 6:1020-1034 (1984).
Moser, H.E. and Dervan, P.B., “Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation”, Science 238: 645-650 (1987).
Ferrin, L.J. and Camerini-Otero, R.D., Selective Cleavage of Human DNA: RecA-Assisted restriction Endonuclease (RARE) Cleavage, Science 254:1494-1497 (1991).
West, S.C., “Enzymes and Molecular Mechanisms of Genetic Recombination”, Annu. Rev. Biochem. 61:603-640 (1992).
Hsieh, P. and Camerini-Otero, R.D., “Formation of Joint DNA Molecules by Two Eukaryotic Strand Exchange Proteins Does Not Require Melting of a DNA Duplex”, The J. of Biol. Chem. vol. 264 9:5089-5097 (1989).
Hsieh, P., et al., “Pairing of Homologous DNA Sequences by Proteins: Evidence for Three-Stranded DNA”, Genes & Development pp. 1951-1963 (1990).
Rao, B.J, et al., “Stable Three-Stranded DNA Made by RecA Protein”, P.N.A.S. USA 88:2984-2988, (1991).
Gruenert Deiter C.
Kunzelmann Karl
Canady Karen S.
Canady & Lortz
Katcheves Konstantina
Ketter James
The Regents of the University of California
LandOfFree
Gene therapy by small fragment homologous replacement does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene therapy by small fragment homologous replacement, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene therapy by small fragment homologous replacement will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3781682