Gene therapy by small fragment homologous replacement

Details Gene therapy by small fragment homologous replacement Gene therapy by small fragment homologous replacement

1995-06-07

2000-01-04

Elliott, George C.

Chemistry: molecular biology and microbiology

Process of mutation, cell fusion, or genetic modification

Introduction of a polynucleotide molecule into or...

435325, 435366, 435371, C12N 510, C12N 1563

Patent

active

060109084

ABSTRACT:
A method for gene therapy using small fragment homologous replacement. The method introduces small fragments of exogenous DNA into regions of endogenous genomic DNA virtually homologous to the exogenous DNA. The exogenous DNA fragments contains sequence modification that correct mutations in the endogenous DNA or introduce mutations that alter cellular or an infecting pathogen phenotype.

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