Gene-targeted mice with humanized A.beta. sequence and Swedish F

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal

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800DIG1, 424 92, 935 63, C12N 500, C12N 1500, A61K 4900

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active

057771944

ABSTRACT:
Disclosed is non-human mouse homozygous for a targeted amyloid precursor protein-encoding gene comprising: (1) a human A.beta. peptide-encoding sequence in place of the native A.beta. peptide-encoding sequence; and (2) Swedish FAD mutations.

REFERENCES:
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