Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Reexamination Certificate
2006-07-25
2006-07-25
Falk, Anne-Marie (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
C800S003000, C800S009000, C800S013000, C800S014000, C800S021000, C800S022000, C435S455000, C435S463000, C435S320100, C435S325000
Reexamination Certificate
active
07081561
ABSTRACT:
The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further provides cells isolated from the gene-targeted animals, which cells produce a recombinant apoE polypeptide displaying domain interaction. The invention further provides methods of identifying agents that reduce apoE4 domain interaction, and which are useful to treat apoE4-related neurological and cardiovascular disorders.
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Dong Li-Ming
Farese Robert V.
Raffai Robert
Weisgraber Karl H.
Borden Paula A.
Bozicevic Field & Francis LLP
Falk Anne-Marie
Field Bret E.
The Regents of the University of California
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