Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2008-03-24
2011-10-04
Salmon, Katherine (Department: 1634)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C536S023100, C536S024300, C435S006120
Reexamination Certificate
active
08030060
ABSTRACT:
A first embodiment is a breast cancer prognosticator comprising a detection mechanism consisting a 15-gene signature. In addition there are embodiments comprised of 23-gene signatures and 28-gene signatures. The 28-gene signature may also be used for the prognosis of ovarian cancer. A second embodiment is a method to determine metastatic potential, relapse potential, or both in breast cancer patients comprising collecting a sample from an individual, removing marker-derived polynucleotide from said sample, using a detection mechanism to search for positive matches of said polynucleotides and either the 15, 23, or 28-gene signatures, and developing a quantitative expression profile. Utilizing risk analysis the individual can be placed into one of two or more groups predicting risk and/or clincopathogic variables. Another embodiment is a method to determine relapse free potential in breast cancer patients comprising collecting a sample from an individual, removing marker-derived polynucleotide from said sample, using a detection mechanism to search for positive matches of said polynucleotides and a 24-gene signature, and developing a quantitative expression profile.
REFERENCES:
patent: 6974667 (2005-12-01), Horne
patent: 7056674 (2006-06-01), Baker
patent: 2003/0224374 (2003-12-01), Dai
Richer et al. (The Journal of Biological Chemistry 2002 vol. 277 p. 5209).
Map2k2 probe Affymetrix 6800 Microarray www.affymetrix.com.
Smarcd2 probe Affymetrix 6800 Microarray www.affymetrix.com.
S100P probe Affymetrix 6800 Microarray www.affymetrix.com.
FAT probe Affymetrix 6800 Microarray www.affymetrix.com.
DDOST probe Affymetrix 6800 Microarray www.affymetrix.com.
SSBP1 probe Affymetrix 6800 Microarray www.affymetrix.com.
PDGFRA probe Affymetrix 6800 Microarray www.affymetrix.com.
INPPL1 probe Affymetrix 6800 Microarray www.affymetrix.com.
RAD50 probe Affymetrix 6800 Microarray www.affymetrix.com.
PLSCR1 probe Affymetrix 6800 Microarray www.affymetrix.com.
RAD52 probe Affymetrix 6800 Microarray www.affymetrix.com.
C18B11 probe Affymetrix 6800 Microarray www.affymetrix.com.
MCM2 probe Affymetrix 6800 Microarray www.affymetrix.com.
MCF2L probe Affymetrix 6800 Microarray www.affymetrix.com.
TXNRD1 probe Affymetrix 6800 Microarray www.affymetrix.com.
Aylor William
Salmon Katherine
West Virginia University
LandOfFree
Gene signature for diagnosis and prognosis of breast cancer... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene signature for diagnosis and prognosis of breast cancer..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene signature for diagnosis and prognosis of breast cancer... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4289260