Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1996-06-07
1999-02-09
Arthur, Lisa B.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
536 235, 4353201, 435325, 935 77, 935 78, C12N 120, C12N 1563, C12N 1585, C07H 2104
Patent
active
058693181
ABSTRACT:
By means of a new molecular cloning technique designated "Alu-splicing PCR", we have isolated a new gene sequence, DSCR1, located in the 21q22.1-q22.2 region. DSCR1 displays a high expression in brain and heart, coding for a new protein with a proline-rich region and with some structural characteristics typical of a protein involved in transcription and/or in protein-protein interactions. The increase in the transient expression of DSCR1 mRNA in brains of young rats compared with the brains of adult rats suggests an important role of DSCR1 during the development of the central nervous system. The overexpression of pSCR1 may be involved in pathogenic abnormalities of mental retardation and/or heart defects in patients with Down syndrome.
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Estivill Palleja Xavier
Fuentes Juan Jose
Pritchard Melanie
Arthur Lisa B.
Estivill Palleja Xavier
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