Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-06-28
1998-11-10
Myers, Carla J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 4351723, 435325, 4352523, 4353201, 536 235, 536 231, 536 2431, 536 2433, 935 4, 935 6, 935 8, 935 9, 935 78, C12Q 168, C12P 1934, C07H 2104
Patent
active
058341838
ABSTRACT:
The present invention provides an isolated DNA molecule of the autosomal dominant spinocerebellar ataxia type 1 gene, which is located within the short arm of chromosome 6. This isolated DNA molecule is preferably located within a 3.36 kb EcoRI fragment, i.e., an EcoRI fragment containing about 3360 base pairs, of the SCA1 gene. The isolated sequences contain a CAG repeat region. The number of CAG trinucleotide repeats (n) is .ltoreq.36, preferably n=19-36, for normal individuals. For an affected individual n>36, preferably n.gtoreq.43.
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Chung Ming-yi
Orr Harry T.
Ranum Laura P. W.
Zoghbi Huda Y.
Myers Carla J.
Regents of the University of Minnesota
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