Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-07
1997-06-17
Myers, Carl J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 235, 536 2431, 536 2433, 935 8, 935 9, 935 10, 935 77, 935 78, C12Q 168, C07H 2104, C12P 1934
Patent
active
056396147
ABSTRACT:
A genetic mutation within the SR calcium release channel provides a test for susceptibility to idiopathic dilated cardiomyopathy. The test detects the presence of the mutation in a sample of nucleic acids obtained from the individual being tested. Restriction fragment length polymorphism is one technique which can be used in the test.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis
Brillantes et al, Circulation Research (1992) 71:18-26.
Otsu et al, Journal Biological Chemistry (1990) 265; 13472-13483.
Chen, et al., "Characterization of a Ca.sup.2+ Binding and Regulatory Site in the Ca.sup.2+ Release Channel (Ryanodine Receptor) of Rabbit Skeletal Muscle Sarcoplasmic Reticulum", The Journal of Biological Chemistry, vol. 267, No. 32, pp. 23318-23326, Nov. 15, 1992.
Fujii, et al., "Identification of a Mutation in Porcine Ryanodine Receptor Associated with Malignant hyperthermia", Science, vol. 253, pp. 448-451, Jul. 26, 1991.
Sen, et al., "Enhanced .alpha..sub.1 -Adrenergic Responsiveness in Cardiomyopathic Hamster Cardiac Myocytes: Relation to the Expression of Pertussis Toxin-Sensitive G Protein and .alpha..sub.1 -Adrenergic Receptors", Circulation Research, vol. 67, No. 5, pp. 1182-1192, Nov. 1990.
Sen, et al., "Inotropic and Calcium Kinetic Effects of Calcium Channel Agonist and Antagonist in Isolated Cardiac Myocytes From Cardiomyopathic Hamsters", Circulation Research, vol. 67, No. 3, pp. 599-608, Sep. 1990.
Sen, et al., "Myocyte Structure, Function, and Calcium Kinetics in the Cardiomyopathic Hamster Heart", The American Physiological Society, pp. H1533-H1543, 1990.
Sen, et al., "T-Type Ca.sup.2+ Channels Are Abnormal in Genetically Determined Cardiomyopathic Hamster Hearts", Circulation Research, vol. 75, No. 1, pp. 149-155, Jul. 1994.
Witcher, et al., "Unique Phosphorylation Site on the Cardiac Ryanodine Receptor Regulates Calcium Channel Activity", The Journal of Biological Chemistry, vol. 266, No. 17, pp. 11144-11152, Jun. 15, 1991.
Tunwell, et al., "Expression Studies With cDNAs Encoding the Human Cardiac Ryanodine Receptor-Calcium Release Channel", Ryanodine Receptor: Molecular Biology and Biochemistry, p. A52, M-Pos136.
Takekura, et al., "Peripheral Couplings and Triads Lack Feet and Tetrads in Dyspedic Mice With a Targeted Mutation of the Gene for Skeletal Muscle Ryanodine Receptor", Ryanodine Receptor: Structure and Function, p. A127, Tu-AM-E1.
Sitsapesan, et al., "Luminal Ca.sup.2+ Regulates the Open Probability of Skeletal SR Ca.sup.2+ -Release Channels Activated by ATP and cADP-Ribose", Ryanodine Receptor: Structure and Function, p. A127, Tu-AM-E3.
Ondrias, et al., "Single Channel Properties of the Full Length and Truncated Cloned Expressed by Anodine Receptor", Ryanodine Receptor: Structure and Function, p. A127, Tu-AM-E5.
Chen, et al., "Rectification of the Calcium Release Channel of Skeletal Muscle Sarcoplasmic Reticulum (Ryanodine Receptor) by FK506 Binding Protein 12", Ryanodine Receptor: Structure and Function, p. A127, Tu-AM-E2.
Kobrinsky, et al., "Functional Properties of the Skeletal Muscle Ryanodine Receptor Expressed in Xenopus Oocytes", Ryanodine Receptor: Structure and Function, p. A127, Tu-AM-E4.
Guo, et al., "Association of Triadin with the Ryanodine Receptor and Calsequestrin in the Lumen of Sarcoplasmic Reticulum", Ryanodine Receptor: Structure and Function, p. A127, Tu-AM-E6.
Lusis Aldons Jake
Philipson Kenneth D.
Sen Luyi
Myers Carl J.
The Regents of the University of California
LandOfFree
Gene mutation in patients with idiopathic dilated cardiomyopathy does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene mutation in patients with idiopathic dilated cardiomyopathy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene mutation in patients with idiopathic dilated cardiomyopathy will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2157021