Gene methylation in cancer diagnosis

Details Gene methylation in cancer diagnosis Gene methylation in cancer diagnosis

2007-05-30

2011-11-29

Kapushoc, Stephen (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C536S023100

Reexamination Certificate

active

08067168

ABSTRACT:
The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use in detecting and diagnosing cancer.

REFERENCES:
patent: 2004/0234960 (2004-11-01), Olek et al.
patent: WO 02/00927 (2002-01-01), None
patent: WO 02/18632 (2002-03-01), None
patent: WO 2007/016668 (2007-02-01), None
GenBank Locus AF369786 ‘Homo sapiensgrowth hormone secretagogue receptor gene, complete cds, alternatively spliced’ (Jul. 7, 2001), from www.ncbi.nlm.nih.gov, 5 printed pages.
Juppner H. Bone (1995) vol. 17 No. 2 Supplement, pp. 39S-42S.
GenBank Locus AC069523 “Homo sapiens3 BAC RP11-1K20 (Roswell Park Cancer Institute Human BAC Library) complete sequence” (Aug. 30, 2002) from www.ncbi.nlm.nih.gov, pp. 1-31.
Rein T. et al. Nucleic Acids Research (1998) vol. 26, No. 10, pp. 2255-2264.
Gaytan F. et al. The Journal of Clinical Endocrinology & Metabolism (Mar. 2005) vol. 90, No. 3, pp. 1798-1804.
Cmaeron E.E. et al Blood (Oct. 1, 1999) vol. 94, No. 7, p. 2445-2451.
Costello, Josoph F. et al.; “Graded Methylation in the Promoter and BOdy of the O6-Methylguanine DNA Methyltransferase (MGMT) Gene Correlates with MGMT Expression in Human Glioma Cells”; 1994,The Journal of Biological Chemistry, vol. 269, No. 25, pp. 17228-17237.
Widschwendter, Martin et al.; “Methylation and Silencing of the Retinoic Acid Receptor-β2 Gene in Breast Cancer”; 2000,Journal of the National Cancer Institute, vol. 92, No. 10, pp. 826-832.
Bae, Young Kyung et al.; “Hypermethylation in histologically distinct classes of breast cancer”; 2004,Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, vol. 10, No. 18, pp. 5998-6005.
Makiyama, K. et al.; “Aberrant expression of HOX genes in human invasive breast carcinoma”; 2005,Oncology Reports, vol. 13, No. 4, pp. 673-679.
Yan, P.S. et al.; “Differential distribution of DNA methylation within the RASSF1A CpG island in breast cancer”; 2003,Cancer Research, vol. 63, No. 19, pp. 6178-6186.

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