Gene knockout mutations that increase peptide production

Details Gene knockout mutations that increase peptide production Gene knockout mutations that increase peptide production

2009-03-05

2010-02-16

Wang, Andrew (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S069700, C435S041000, C435S183000, C435S440000, C435S471000

Reexamination Certificate

active

07662587

ABSTRACT:
Disrupting the expression of endogenousEscherichiahost cell genes gcvA and spr provides mutant host cells having increased heterologous peptide production relative to controlEscherichiahost cells. RecombinantEscherichiahost cells are provided as well as methods of using such host cells for heterologous peptide production.

REFERENCES:
Wilson et al. Journal of Bacteriology 1993, vol. 175, No. 16, pp. 5129-5134. Role of the GcvA and PurR Proteins in Negative Regulation of theEscherichia coliGlycine Cleavage Enzyme System.
Ghrist et al. Microbiology (2001), 147, 2215-2221. GcvR interacts with GcvA to inhibit activation of theEscherichia coliglycine cleavage operon.
Chen et al., Biotechnology and Bioengineering, 85(5):463-474 (2004).
Baba et al., Molecular Systems Biology, Article No. 2006.0008 (2006).

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