Gene involved in CADASIL, method of diagnosis and...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S069100, C435S091100, C435S091200

Reexamination Certificate

active

07138234

ABSTRACT:
The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL and related diseases.

REFERENCES:
patent: 2116628 (1994-02-01), None
Munoz et al., Can. Med. Assoc. Journal 162: 65-72, 2000.
Burgess et al.,The Journal of Cell Biology,111:2129-2138 (1990).
Ducros et al., “Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, Genetic Homogeneity, and Mapping of the Locus Within a 2-cM Interval”,Am. J. Hum. Genet.58:171-181 (1996).
Joutel et al., “Notch3 Mutations in CADASIL, a Hereditary Adult-Onset Condition Causing Stroke and Dementia”,Nature383:707-710.
Joutel et al., “Identification of the CADASIL Gene”,Stroke28(1):246, Abstract 65 (1997).
Joutel et al., “Identification of Expressed Sequences From the CADASIL Region on 19p”,Amer. J. of Human Genet.57(3):A342, Abstract 1985 (1995).
Lardelli et al., “Expression of the Notch 3 Intracellular Domain in Mouse Central Nervous System Progenitor Cells is Lethal and Leads to Disturbed Neural Tube Development”,Mech. of Develop.59:177-190 (1996).
Lardelli et al., “The Novel Notch Homologue Mouse Notch 3 Lacks Specific Epidermal Growth Factor-Repeats and is Expressed in Proliferating Neuroepithelium”,Mech. of Develop.46:123-136 (1994).
Larsson, C., et al., “The Human NOTCH1, 2, and 3 Genes Are Located at Chromosome Positions 9q34, 1p13-p11, and 19p.13.2-p13.1 in Regions of Neoplasia-Associated Translocation,”Genomics24(2):253-258 (1994).
Lindsell et al., “Expression Patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 Genes Identify Ligand-Receptor Pairs That May Function in Neural Development”,Mol. and Cell. Neuroscience8:14-27 (1996).
Ophoff et al., “Gene for Familial Hemiplegic Migraine on Chromosome 19p13”,Posters: Molecular Etiology of Disease,vol. 57, No. 4, pp. A222, Abstract 1284 (1995).
Rudinger et al., in “Peptide Hormones”, edited by Parsons, J.A., University Park Press, Jun. 1976, p. 6.
Sambrook, J., et al., “Molecular Cloning, A Laboratory Manual,” 2nd, 16.1-16.81 (1989).
Bork, Peer et al., “Sequences and Topology Deriving Biological Knowledge from Genomic Sequences,”Current Opinion in Structural Biology,vol. 8, pp. 331-322 (1998).
Del Amo, Francisco Franco et al., “Expression Pattern of Motch, a Mouse Homolog of Drosophila Notch, Suggest and Important Role in Early Postimplantation Mouse Development,” vol. 115, pp. 737-744 (1992).
Skolnick, Jeffrey et al., “From Genes to Protein Structure and Function: Novel Applications of Computational Approaches in the Genomic Era,”Trends in Biotech.,vol. 18(1), pp. 34-39 (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Gene involved in CADASIL, method of diagnosis and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gene involved in CADASIL, method of diagnosis and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene involved in CADASIL, method of diagnosis and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3643748

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.