Gene functionally related to dyslexia

Details Gene functionally related to dyslexia Gene functionally related to dyslexia

2008-04-08

2008-04-08

Goldberg, Jeanine A. (Department: 1634)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C435S006120, C435S091100, C435S091200

Reexamination Certificate

active

07355022

ABSTRACT:
The present invention describes a novel human gene, DYXC1, which is functionally related to dyslexia. DYXC1 gene encodes a 420-amino acid residue protein. DYXC1 is expressed in several tissues, including the brain, and is localized in the nucleus. In addition, four single nucleotide polymorphisms (SNPs) in DYXC1 mRNA have been characterized in this invention. The invention provides diagnostic methods and materials for analysing allelic variation in DYXC1 gene. This invention also provides polypeptides encoded by DYXC1 gene and antibodies binding to said polypeptides.

REFERENCES:
patent: 5474796 (1995-12-01), Brennan
patent: 2003/0092019 (2003-05-01), Meyer et al.
Marino et al. (E. J. Human Genetics, vol. 13, pp. 491-499, 2005).
Hirschhorn et al. (Genetics in Medicine. vol. 4, No. 2, pp. 45-61, Mar. 2002).
Ioannidis (Nature Genetics, vol. 29, pp. 306-309, Nov. 2001).
Scerri et al. (J. Med. Genet. vol. 41, pp. 853-857, 2004).
Wigg et al (Mol. Psychiatry, vol. 9, pp. 1111-1121, 2004).
Taipale et al. (Genbank Accession No. AF337549, Feb. 2, 2002).
Applied Biosystems Product Catalog (1993, pp. 135-157, 160-164).
NIH-MGC (Genbank Accession No. BE972748, Oct. 4, 2000).
Elena L. Grigorenko,J. Child Psychol.Psychiat., vol. 42, No. 1, (2001), pp. 91-125.
E.L. Grigorenko et al.,Am. J. Hum. Genet., vol. 60, (1997), pp. 27-39.
M.M. Nothen et al.,European Child&Adolescent Psychiatry, vol. 8, Suppl. 3, (1999), pp. 56-59.
Jaana Nopola-Hemmi et al.,J. Med. Genet., vol. 37, (2000), pp. 741-775.
Jaanamarja Nopola-Hemmi,Academic Dissertation, Helsinki University Biomedical Dissertations No. 16, Department of Pediatric Neurology and Department of Medical Genetics, University of Helsinki, Finland, (Sep. 2002).
M. Taipale et al.,NCBI, Accession No. AF337549.1,Homo sapiensEKN1, (Jan. 17, 2001).
M. Taipale et al.,NCBI, Accession No. AAL73230, EKN1 (Homo sapiens), (Jan. 17, 2001).
N. Kaminen et al.,NCBI, Accession No. AY178583,Pan troglodytesEK1, (Nov. 13, 2002).
N. Kaminen et al.,NCBI, Accession No. AY178592,Pan paniscusEKN1, (Nov. 13, 2002).
N. Kaminen et al.,NCBI, Accession No. AY178601,Gorilla gorillaEKN1, (Nov. 13, 2002).
N. Kaminen et al.,NCBI, Accession No. AY178610,Pongo pygmaeusEKN1, (Nov. 13, 2002).
M. Taipale et al.,EBI, Swall Accession No. Q8WXU2, EKNI (Human), (Mar. 1, 2002).
M. Taipale et al.,NCBI, Accession No. AF337549.1,Homo sapiensEKN1, (Feb. 2, 2002).

Affiliated with

Also associated with

Rating

Gene functionally related to dyslexia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gene functionally related to dyslexia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene functionally related to dyslexia will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2778772