Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1994-01-18
1997-02-25
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
536 235, C07K 14475, A61K 3818, C12N 1512
Patent
active
056060297
ABSTRACT:
A growth factor protein similar in structure and function to hepatocyte growth factor has been discovered along with the DNA and cDNA coding for this in both the mouse and human. The DNA includes 18 exons and is homologous to DNA at the D3F15S2 locus on human chromosome 3; a region predicted to code for one or more tumor suppressor genes.
REFERENCES:
patent: 5219991 (1993-06-01), Leonard et al.
Skeel, Alison, Macrophage Stimulating Protein: Purification, Partial Amino Acid Sequence, and Cellular Activity, The Journal of Experimental Medicine, vol. 173, pp. 1227-1234.
Han et al. Biochemistry 30(40): 9768-80 (1991).
Degen et al. Biochemistry 30(40): 9781-91 (1991).
Naylor et al. Nature 329:451-54 (1987).
Harbour et al. AntiCancer Res. 10:23-28 (1990).
Naylor et al. Genomics 4:355-61 (1989).
Children's Hospital Medical Center
Saoud Christine
Ulm John
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