Gene family of tumor-associated antigens

Details Gene family of tumor-associated antigens Gene family of tumor-associated antigens

1988-12-29

1993-02-09

Doll, John

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 691, 435 693, 435 711, 935 1, 935 6, 935 12, 935 60, 530395, 530828, 536 235, C12N 1500, C12P 2106, C07K 1300, C07H 2100

Patent

active

051852543

ABSTRACT:
A tumor-associated antigen, GA733-1, has been discovered which shares sequence homology with both thyroglobulin type I and interleukin-2 receptors. The antigen is highly expressed in pancreatic carcinoma cells. The antigen is similar to a previously described tumor-associated antigen found in colorectal carcinoma cells. The gene for the antigen is fully sequenced and described here.

REFERENCES:
Beauchemin et al Mol Cell Biol 7(9):3221, 1987.
Ross et al Biochem Biophys Res. Comm. 135:297, 1986.
Proc. Natl. Acad. Sci. USA, vol. 87, pp. 3542-3546, dated May 1990 Entitled: "Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2", by Stanislaw Szala, et al.

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