Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1998-02-27
2000-09-05
Chan, Christina Y.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530325, 530326, 530827, 530839, 530350, A61K 3817, C07K 14435, C07K 1900
Patent
active
061145025
ABSTRACT:
Nucleic acid compositions are provided that encode a family of mammalian proteins expressed in the retina and brain. Members of the gene family are genetically linked to various neurosensory defects, including cochlear degeneration, peripheral retinal degeneration and cone-rod retinal dystrophy. The nucleic acid compositions find use in identifying DNA sequences encoding homologous or related proteins; for production of the encoded protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of neurosensory defects, identification of retinal cells based on expression, and the like. The DNA is further used as a diagnostic for genetic predisposition to the linked neurosensory defect.
REFERENCES:
patent: 5646040 (1997-07-01), Kleyn et al.
patent: 5686598 (1997-11-01), North et al.
Coleman and Eicher, "Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse," Journal of Heredity (1990) vol. 81:424-427.
Jones, et al., "Localization of Insulin-2 (Ins-2) and the Obesity Mutant Tubby (tub) to Distinct Regions of Mouse Chromosome 7," Genomics (1992) vol. 14:197-199.
Lee, et al., "Abnormal Splicing of the Leptin Receptor in Diabetic Mice," Nature (Feb. 1996) vol. 379:632-635.
Nishina, et al., "Characterization of Plasma Lipids in Genetically Obese Mice: The Mutants Obese, Diabetes, Fat, Tubby, and Lethal Yellow," Metabolism (May 1994) vol. 43:549-553.
Noben-Trauth, Konrad, et al., "A Candidate Gene for the Mouse Mutation Tubby", Nature (Apr. 11, 1996) vol. 380:534-538.
North, Michael A., et al., "Molecular Charaterization of TUB, TULP1, and TULP2, members of the Novel Tubby Gene Family and Their possible Relation to Ocular Diseases," Proc. Natl. Acad. Sci. USA (Apr. 1997) vol. 94:3128-3133.
Ohlemiller, at al., "Cochlear and Retinal Degeneration in the Tubby Mouse," NeuroReport (Apr. 1995) vol. 6:845-849.
Samuelson, et al., "Localization of the Murine Cholecystokinin A and B Receptor Genes," Mammalian Genome (1995) vol. 6: 242-246.
Zhang, et al., "Positional Cloning of the Mouse Obese Gene and its Human Homologue," Nature (Dec. 1994) vol. 372:425-432.
Naggert Juergen
Nishina Patsy
Noben-Trauth Konrad
North Michael
AxyS Pharmaceuticals, Inc.
Borden Paula A.
Chan Christina Y.
Sherwood Pamela J.
VanderVegt F. Pierre
LandOfFree
Gene family associated with neurosensory defects does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene family associated with neurosensory defects, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene family associated with neurosensory defects will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2213341