Gene expression suppression agents

Details Gene expression suppression agents Gene expression suppression agents

2011-06-21

2011-06-21

Zara, Jane (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S006120, C435S091100, C435S091310, C435S320100, C536S023100, C536S024500

Reexamination Certificate

active

07964714

ABSTRACT:
A method is provided for making gene suppression agents to be used in eukaryotic cells by using a recombinant DNA construct containing at least one transcriptional unit compromising a transcriptional promoter, a template sequence for making a RNA molecule, and a transcriptional terminator. Mechanisms of the RNA mediated gene suppression include, but are not limited to, RNA interferences (RNAi). The use of the agents as tools for biomedical research as well as medicinal products is also disclosed.

REFERENCES:
patent: 5580761 (1996-12-01), Greatbatch et al.
patent: 5610015 (1997-03-01), Wickens et al.
patent: 5624803 (1997-04-01), Noonberg et al.
patent: 5677131 (1997-10-01), Wickens et al.
patent: 5683902 (1997-11-01), Hampel et al.
patent: 5723323 (1998-03-01), Kauffman et al.
patent: 5750667 (1998-05-01), Wickens et al.
patent: 5763192 (1998-06-01), Kauffman et al.
patent: 5807743 (1998-09-01), Stinchcomb et al.
patent: 5814476 (1998-09-01), Kauffman et al.
patent: 5817483 (1998-10-01), Kauffman et al.
patent: 5824514 (1998-10-01), Kauffman et al.
patent: 5837503 (1998-11-01), Doglio et al.
patent: 5840555 (1998-11-01), Oshima et al.
patent: 5869248 (1999-02-01), Yuan et al.
patent: 5877162 (1999-03-01), Werner et al.
patent: 5902880 (1999-05-01), Thompson
patent: 5976862 (1999-11-01), Kauffman et al.
patent: 5994526 (1999-11-01), Meulewaeter et al.
patent: 5998193 (1999-12-01), Keese et al.
patent: 6025192 (2000-02-01), Beach et al.
patent: 6033856 (2000-03-01), Koerner et al.
patent: 6057153 (2000-05-01), George et al.
patent: 6057156 (2000-05-01), Akhtar et al.
patent: 6074836 (2000-06-01), Bordignon et al.
patent: 6080575 (2000-06-01), Heidtmann et al.
patent: 6103890 (2000-08-01), Jarvis et al.
patent: 6107078 (2000-08-01), Keese et al.
patent: 6127173 (2000-10-01), Eckstein et al.
patent: 6146886 (2000-11-01), Thompson
patent: 6183959 (2001-02-01), Thompson
patent: 6255071 (2001-07-01), Beach et al.
patent: 6280936 (2001-08-01), Burgin et al.
patent: 6294711 (2001-09-01), Meulewaeter et al.
patent: 6300131 (2001-10-01), Greider et al.
patent: 6326193 (2001-12-01), Liu et al.
patent: 6346398 (2002-02-01), Pavco et al.
patent: 6380170 (2002-04-01), Muller et al.
patent: 6506559 (2003-01-01), Fire et al.
patent: 2003/0084471 (2003-05-01), Beach et al.
patent: 2005/0014263 (2005-01-01), Moyer et al.
patent: 2006/0122381 (2006-06-01), Streb et al.
patent: WO 01/92513 (2001-12-01), None
patent: WO 02/44321 (2002-06-01), None
Jennings, P.A. et al., EMBO J., vol. 6, No. 10, pp. 3043-3047 (1987).
Hallenberg et al., Biochimica et Biophysica Acta, vol. 91565, pp. 169-173 (2001).
Paule et al., Nucleic Acids Res., vol. 28, No. 6, pp. 1283-1298 (2000).
Willis, I. M.., Eur. J. Biochem., vol. 212, pp. 1-11 (1993).
Bitko et al., “Phenotypic silencing of cytoplasmic genes . . . ,” BMC Microbiology, 2001, 17 pages, 1: 34, Mobile, Alabama, USA.
Kuwabara et al., “A Novel Allosterically trans-Activated . . . ,” Molecular Cell, 1998, pp. 617-627, vol. 2, Tokyo, Japan.
Wong-Staal, “Ribozyme gene therapy for HIV infection,” Advanced Drug Delivery Reviews 17, 1995, pp. 363-368, San Diego, CA, USA.
Caplen et al., “Specific inhibition of gene expression by small . . . ,” PNAS, 2001, pp. 9742-9747, vol. 98, No. 17, Baltimore, Maryland, USA.
Sui et al., “A DNA vector-based RNAi technology . . . ,” PNAS, 2002, pp. 5515-5520, vol. 99, No. 8, Boston, MA, USA.
Yu et al., “RNA interference by expression of . . . ,” PNAS, 2002, pp. 6047-6052, vol. 99, No. 9, Ann Arbor, MI, USA.
Brummelkamp et al., “A System for Stable Expression . . . ”, Science Magazine, 2002, pp. 550-553, vol. 296.
Lee et al., “Expression of small interfering RNAs targeted . . . ”, Nature Biotechnology, 2002, pp. 500-505, vol. 20.

Affiliated with

Also associated with

Rating

Gene expression suppression agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gene expression suppression agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene expression suppression agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2714787