Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-12-13
2005-12-13
Sitton, Jehanne (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C536S023100, C536S024300
Reexamination Certificate
active
06974667
ABSTRACT:
The present invention identifies the global changes in gene expression associated with liver cancer by examining gene expression in tissue from normal liver, metastatic malignant liver and hepatocellular carcinoma. The present invention also identifies expression profiles which serve as useful diagnostic markers as well as markers that can be used to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.
REFERENCES:
Timothy J. Yeatman et al., Identification of a differentially-expressed message associated with colon cancer liver metastasis . . . , (1995) Oxford University Press, Nucleic Acids Research, vol. 23, No. 19, pp. 4007-4008.
Naohiro Tomita, Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissue, (Dec. 1987), vol. 225, pp. 113-119.
Yoshitaka Ohmachi et al., Expression of the pancreatic secretory trypsin inhibitor gene in the liver infected with hepatitis B virus, Journal of Hepatology (1994), pp. 1012-1016.
Chen CJ, Yu MW and Liaw YF. Epidemiological characteristics and risk factors of hepatocellular carcinoma. J Gastroenterol Hepatol. Oct. 1997;12(9-10):S294-308.
Di Carlo V, Ferrari G, Castoldi R, Nadalin S, Marenghi C, Molteni B, Taccagni G and Castrucci M. Surgical treatment and prognostic variables of hepatocellular carcinoma in 122 cirrhotics. Hepatogastroenterology. Jul. 1995;42(3):222-9.
Hsu DK, Dowling CA, Jeng KC, Chen JT, Yang RY and Liu FT. Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma. Int J Cancer. May 17, 1999;81(4):519-26.
Iurisci I, Tinari N, Natoli C, Angelucci D, Cianchetti E and Iacobelli S. Concentrations of galectin-3 in the sera of normal controls and cancer patients. Clin Cancer Res. Apr. 2000;6(4):1389-93.
Jiang WG, Bryce RP, Horrobin DF and Mansel RE. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. Biochem Biophys Res Commun. Mar. 17, 1998;244(2):414-20.
Johnson RC. Hepatocellular carcinoma. Hepatogastroenterology. Jan.-Feb. 1997;44(13):307-12.
Kurata T, Oguri T, Isobe T, Ishioka S and Yamakido M. Differential expression of facilitative glucose transporter (GLUT) genes in primary lung cancers and their liver metastases. Jpn J Cancer Res. Nov. 1999;90(11):1238-43.
Li D and Mrsny RJ. Oncogenic Raf-1 disrupts epithelial tight junctions via downregulation of occludin. J Cell Biol. Feb. 21, 2000;148(4):791-800.
Morita K, Furuse M, Fujimoto K and Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A. Jan. 19, 1999;96(2):511-6.
Nakamura M, Inufusa H, Adachi T, Aga M, Kurimoto M, Nakatani Y, Wakano T, Nakajima A, Hida JI, Miyake M, Shindo K and Yasutomi M. Involvement of galectin-3 expression in colorectal cancer progression and matastasis. Int J Oncol. Jul. 1999;15(1):143-8.
Ohmachi Y, Murata A, Matsuura N, Yasuda T, Yasuda T, Monden M, Mori T, Ogawa M and Matsubara K. Specific expression of the pancreatic-secretory-trypsin-inhibitor (PSTI) gene in hepatocellular carcinoma. Int J Cancer. Nov. 11, 1993;55(5):728-34.
Simon DB, Lu Y, Choate KA, Velazquez H, Al-Sabban E, Praga M, Casari G, Bettinelli A, Colussi G, Rodriguez-Soriano J, McCredie D, Milford D, Sanjad S and Lifton RP. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science. Jul. 2, 1999;285(5424):103-6.
Weinberg RA. Tumor suppressor genes. Science. Nov. 22, 1991;254(5035):1138-46.
Zak J, Schneider SW, Eue I, Ludwig T and Oberleithner H. High-resistance MDCK-C7 monolayers used for measuring invasive potency of tumour cells. Pflugers Arch. May 2000;440(1):179-83.
Horne Darci T.
Scherf Uwe
Vockley Joseph
Gene Logic Inc.
Morgan & Lewis & Bockius, LLP
Sitton Jehanne
LandOfFree
Gene expression profiles in liver cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene expression profiles in liver cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene expression profiles in liver cancer will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3521509