Gene expression in mammalian cells using a cap independent 5' no

Details Gene expression in mammalian cells using a cap independent 5' no Gene expression in mammalian cells using a cap independent 5' no

1992-05-18

1994-10-25

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352402, 4353201, 4352351, C12N 510, C12N 1585, C12P 2102

Patent

active

053588568

ABSTRACT:
A construct which includes a cap independent 5' noncoding region of viral or cellular origin and a nucleotide sequence of interest, which is located downstream of the noncoding region. A method of producing a protein or a polypeptide of interest by introducing the construct, including a nucleotide sequence encoding the protein or the polypeptide of interest, into mammalian cells is also described. In one embodiment, the construct comprises all or a portion of the poliovirus cap independent 5' noncoding region and a nucleotide sequence encoding a protein or a polypeptide of interest.

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