Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-08-30
2005-08-30
Fredman, Jeffrey (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S004000, C435S091200
Reexamination Certificate
active
06936417
ABSTRACT:
Methods for analyzing tumor cells, particularly bladder tumor cells employ gene expression analysis of samples. Gene expression patterns are formed and compared to reference patterns. Alternatively gene expression patterns are manipulated to exclude genes which are expressed in contaminating cell populations. Another alternative employs subtraction of the expression of genes which are expressed in contaminating cell types. These methods provide improved accuracy as well as alternative basis for analysis from diagnostic and prognostic tools currently available.
REFERENCES:
patent: 5677125 (1997-10-01), Holt et al.
patent: 5700637 (1997-12-01), Southern
patent: 6458566 (2002-10-01), Alland et al.
patent: 198 18 619 (1999-10-01), None
patent: 96/30389 (1996-10-01), None
patent: 97/16206 (1997-05-01), None
patent: 97/28446 (1997-08-01), None
patent: 98/53319 (1998-11-01), None
patent: 99/47674 (1999-09-01), None
Lokeshwar et al, Cancer Letters. (1998) 131:21-27.
Genbank Accession No. D42046.
Inoue et al, Arch. Histol. Cytol. (1992) 55 Suppl. 157-163 Abstract Only.
Carbin et al, “Urine-TPA (Tissue polypeptide antigen), flowcytometry and cytology as markers for tumor invasiveness in urinary bladder carcinomas”, Urological Research (1989) 17:269-272.
Nathrath et al, “Distribution of Tissue polypeptide antigen in normal human tissues”, J. Histochem. Cytochem. (1985) 33(2):99-109 (Abstract Only).
Liebert et al, “Characteristics of invasive bladder cancers, histological and molecular markers”, Seminars in Urologic Oncology, (1996) 14:62-72.
Liebert et al., “Identification of New Biomarkers for Bladder Cancer Using the Differential Display Reverse Transcriptase Polymerase Chain Reaction”, Proc. Am. Assn. Cancer Res. 38:287, Abstract 1928.
Liebert et al., “Novel Molecular Markers for Bladder Cancer Revealed By Differential Display Reverse Transcriptase Polymerase Chain Reaction”, J. Urol. 159(5 suppl.) 286, Abstract 1101.
Peter S. Nelson, et al., “An Expressed-Sequence-Tag Database of the Human Prostate: Sequence Analysis of 1168 cDNA Clones”, Genomics 47, pp. 12-15, 1998.
David B. Krizman, et al., “Construction of a Representative cDNA Library from Prostatic Intraepithelial Neoplasia”, Cancer Research 56, pp. 5380-5383, Dec. 1, 1996.
Victoria Hawkins, et al., “PEDB: The Prostate Expression Database”, Nucleic Acids Research, vol. 27, No. 1, pp. 240-208, 1999.
Lin Zhang, et al., “Gene Expression Profiles in Normal and Cancer Cells”, Science, vol. 276, pp. 1268-1272.
Torben F. Orntoft, et al., “Molecular Alterations in Bladder Cancer”, United Editorial, XP-000971351, Nov. 11, 1997.
Margaret A. Knowles, et al., Molecular Genetics of Bladder Cancer: Pathways of Development and Progression, Cancer Surveys, vol. 31, pp. 49-76, 1998.
AROS Applied Biotechnology ApS
Fredman Jeffrey
LandOfFree
Gene expression in bladder tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene expression in bladder tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene expression in bladder tumors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3524013