Gene expression control DNA element and associated protein

Details Gene expression control DNA element and associated protein Gene expression control DNA element and associated protein

2007-10-09

2011-12-20

Kaushal, Sumesh (Department: 1633)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S004000, C435S006110, C435S006120, C435S006140, C435S069100, C536S023100, C536S023500

Reexamination Certificate

active

08080376

ABSTRACT:
Through screening of an expression library, a cDNA sequence has been identified that encodes a protein that interacts with human CD33, the DNA being highly homologous to a portion of the human dystrophin gene. A region of that cDNA has been identified as an important regulatory element in controlling expression, both transcription and translation, of the DNA with which it is associated. This DNA sequence element may be used as a regulatory cassette in conjunction with any suitable gene, to modify gene expression. The putative controlling DNA sequence element contains a minimum of 137 base pairs (FIG.1) to 147 base pairs (FIG.1A) and a maximum of 287 base pairs (FIG.1B).

REFERENCES:
patent: 5239060 (1993-08-01), Kunkel et al.
patent: 5430129 (1995-07-01), Campbell et al.
patent: 5858661 (1999-01-01), Shiloh
patent: 5985846 (1999-11-01), Kochanek et al.
patent: 6011137 (2000-01-01), Pirozzi et al.
patent: 6063576 (2000-05-01), Keating et al.
patent: 6083750 (2000-07-01), Chamberlain et al.
patent: 6087108 (2000-07-01), Bandman et al.
patent: 6087111 (2000-07-01), Tinsley et al.
patent: WO 97/22696 (1997-06-01), None
Ahn, A. H., and Kunkel, L. (1993). The structural and functional diversity of dystrophin.Nature Genetics, 3: 283-291.
Alexander, E. L., and Sanders, S. K. (1977). F(ab′)2 reagents are not required if goat, rather than rabbit, antibodies are used to detect human surface immunoglobulin.J Immunol, 119: 1084-1088.
Anderson, S. J., Chou, H. S., and Loh, D. Y. (1988). A conserved sequence in the T-cell receptor beta-chain promoter region.Proc. Natl. Acad. Sci. USA, 85: 3551-3554.
Aruffo, A. and B. Seed (1987). Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.PNAS(USA) 84: 8573-8577.
Aruffo, A., Stamenkovic, I., Melnick, M., Underhill, C.B., and Seed, B. (1990). CD44 Is the Principal Cell Surface Receptor for Hyaluronate.Cell, 61: 1303-1313.
Atkins, J. F., Weiss, R. B., Thompson, S., and Gesteland, R. F. (1991). Towards a genetic dissection of the basis of triplet decoding, and its natural subversion: programmed reading frame shifts and hops.Annu. Rev. Genet., 25: 201-228.
Ausubel, F. M., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A., and Stuhl, K. (1993). In Current Protocols in Molecular Biology, (New York: John Wiley & Sons, Inc.).
Baneiji, J., Rusconi, S., and Schaffner; W. (1981). Expression of a β globin gene is enhanced by remote SV40 DNA sequences.Cell, 27: 299-308.
Baranger, A. M. et al. (1995). Mechanism of DNA-binding enhancement by the human T-cell leukaemia virus transactivator Tax.Nature, 376: 606-608.
Barber, E. K., and Simmons, D.L. (1993). Functional-analysis of the early hematopoietic surface-markers CD33 and CD34.J. Cell. Biochem., 17a: 346.
Barclay, A. N., Birkeland, M.L., Brown, M. L., Beyers, A. D., Davis, S.J., Somoza, C., and Williams, A.F. (1993). The Leucocyte Antigen Facts Book. 424. Academic Press Limited.
Bass, B. L., and Weintraub, H. (1987). A developmentally regulated activity that unwinds RNA duplexes.Cell, 48: 607-613.
Baumhueter, S., Singer, M.S., Henzel, W., Hemmerich, S., Renz, M., Rosen, S.D., and Lasky, L.A. (1993). Binding of L-Selectin to the Vascular Sialomucin CD34.Science, 262: 436-438.
Bishop, J.M.,Annu. Rev. Biochem., 52: 301-354, 1983.
Blackwood, E.M. and R.N. Eisenman,Science, 251: 1211-1217, 1991.
Blake, D. J., Tinsley, J.M., and Davies, K.E. (1994). The emerging family of dystrophin-related proteins.Tr. in Cell Biol., 4: 19-23.
Braun, R. E. (1990). Temporal translational regulation of the protamine 1 gene during mouse spermatogenesis.Enzyme, 44: 120-128.
Britten, R.J. (1994). Evidence that most humanAlusequences were inserted in a process that ceased about 30 million years ago.Proc. Natl. Acad. Sci. 91: 6148-6150.
Bucher, P. (1990). Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences.J. Mol. Biol., 212: 563-578.
Capon, D.J.et al. (1989). Designing CD4 immunoadhesins for AIDS therapy.Nature337: 525-531.
Chelly, J.et al. (1990). Effect of dystrophin gene deletions on mRNA levels and processing in Duchenne and Becker muscular dystrophies.Cell63: 1239-1248.
Chelly, J. et al. (1988). Transcription of the dystrophin gene in human muscle and non-muscle tissue.Nature, 333: 858-860.
Chelly, J., Montarras, D., Pinset, C., Berwald, N. Y., Kaplan, J. C., and Kahn, A. (1990). Quantitative estimation of minor mRNAs by cDNA-polymerase chain reaction. Application to dystrophin mRNA in cultured myogenic and brain cells.Eur. J. Biochem, 187: 691-698.
Chirgwin, J. M., Przybyla, A.E., MacDonald, R.J., and Rutter, W.J. (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.Biochemistry, 18: 5294-5299.
Church, G.M., and Gilbert, W. (1984). Genomic Sequencing.Proc. Natl. Acad. Sci. USA, 81: 1991-1995.
Claros, M. G., and von Heijne, G. (1994). TopPred II: an improved software for membrane protein structure predictions.CABIOS, 10: 685-686.
Cole, S. R., Ashman, L. K., and Ey, P. L. (1987). Biotinylation: An Alternative to Radioiodination for the Identification of Cell Surface Antigens in Immunoprecipitates.Mol. Immunol., 24: 699-705.
Croce, C. M., Erikson, J., Ar-rushdi, A., Aden, D. and Nishikura, K. (1984). Translocated c-myc oncogene of Burkitt lymphoma is transcribed in plasma cells and repressed in lymphoblastoid cells.Proc. Natl. Acad. Sci. USA, 81: 3170-3174.
Crocker, P.R. et al. (1994). Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains.The EMBO Journal13: 4490-4503.
Darnell, J., Lodish, R, and Baltimore, D. (1986). Molecular Cell Biology. 1192. Scientific American Books.
Davidson, N. O. (1993). Apolipoprotein B mRNA editing: a key controlling element targeting fats to proper tissue.Ann. Med., 25: 539-543.
Dornfeld, K. J., and Livingston, D. M. (1992). Plasmid recombination in a rad52 mutant ofSaccharomyces cerevisiae. Genetics, 131: 261-276.
Drysdale, C. M., Duenas, E., Jackson, B.M., Reusser, U., Braus, G.H., and Hinnebusch, A.G. (1995). The transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acids.Mol. Cell Biol., 15: 1220-1233.
Dynan, W. S., and Tjian, R. (1983). The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter.Cell, 35: 79-87.
Eliceiri, B., Labella, T., Hagino, Y., Srivastava, A., Schlessinger, D., Pilia, G., Palmieri, G., and D'Urso, M. (1991). Stable integration and expression in mouse cells of yeast artificial chromosomes harboring human genes.Proc Natl Acad Sci USA, 88: 2179-2183.
Emerson, S. G., Reilly, P., and Cone, R. E. (1979). Differential radiolabelling of lymphocyte membrane alloantigens and immunoglobulins: variation of H2O2 concentration during lactoperoxidase catalyzed cell surface radio-iodination.J. Immunogenet, 6: 87-97.
Fawcett, J., Holness, C.L., and Simmons, D.L. (1994). Molecular Tools for the Analysis of Cell Adhesion.Cell Adhesion and Communication, 2: 275-285.
Feinberg, A. P., and Vogelstein, B. (1983). A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.Analytical Biochemistry, 132: 6-13.
Firtel, R. A. (1981). Multigene families encoding actin and tubulin.Cell, 24, 6-7. Freeman, S. D., Kelm S., Barber, E.K., and Crocker, P.R. (1995). Characterisation of CD33 as a new member of the sialoadhesin family of cell adhesion molecules.Blood, 85: 2005-2012.
Freeman, S.D. et al.,Blood, 85: 2005-2012, 1995.
Gangopadhyay, S.B., Sherratt, T.G., Heckmatt, J.Z., Dubowitz, V., Miller, G., Shokeir, M., Ray, P.N, Strong, P.N. and Worton, R.G. (1992). Dystrophin in frameshift deletion patients with Becker muscular dystrophy.Am. J. Hunt Genet. 51: 562-570.
Garvin, A. M. Pawar, S., Marth, J. D., and Perlmutter, R. M. (1988). Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line.Mol. Cell Biol., 8: 3058-3064.
Gellert, M. (1992). Molecular analysis of V(D)J recombination.Annu. Rev. Genet., 22: 42

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