Gene expression control DNA element and associated protein

Details Gene expression control DNA element and associated protein Gene expression control DNA element and associated protein

2001-09-28

2008-05-13

Kaushal, Sumesh (Department: 1633)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S325000, C435S455000, C536S023100, C536S023500

Reexamination Certificate

active

07371540

ABSTRACT:
Through screening of an expression library, a cDNA sequence has been identified that encodes a protein that interacts with human CD33, the DNA being highly homologous to a portion of the human dystrophin gene. A region of that cDNA has been identified as an important regulatory element in controlling expression, both transcription and translation, of the DNA with which it is associated. This DNA sequence element may be used as a regulatory cassette in conjunction with any suitable gene, to modify gene expression. The putative controlling DNA sequence element contains a minimum of 137 base pairs (FIG.1) to 147 base pairs (FIG.1A) and a maximum of 287 base pairs (FIG.1B).

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