Gene expression control

Details Gene expression control Gene expression control

1998-05-07

2000-10-17

Schwartzman, Robert A.

Chemistry: molecular biology and microbiology

Vector, per se

536 231, 536 241, 536 245, C07H 2104, C07H 2102

Patent

active

061330248

ABSTRACT:
The present invention relates to new vectors, pharmaceutical compositions containing them, and their therapeutical uses. More particularly, it relates to new molecules capable of acting, in a very selective and efficacious way, on the expression of genes.

REFERENCES:
patent: 5624803 (1997-04-01), Noonberg et al.
patent: 5700657 (1997-12-01), Beaudry et al.
Branch et al. "A Good Antisense is Hard to Find" TIBS vol. 23:45-50, Feb. 1998.
Stull et al. "Antigene, Ribozyme and Aptamer Nucleic Acid Drugs: Progress and Prospects" Pharmaceutical Research vol. 12(4):465-483, 1995.
Orkin et al. "Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy", Dec. 7, 1995.
Giovannangeli et al., Oligonucleaotide clamps arrest DNA synthesis on a single-stranded DNA target, Proc. Natl. Acad. Sci., USA, 90, 10013-10017 (1993).
Giovannangeli et al., Single-Stranded DNA as a Target for Triple-Helix Formation, J. Am. Chem. Soc., 113, 7775-7777 (1991).
Helene, The anti-gene strategy: control of gene expression by triple-forming-oligonucleotides, Anti-Cancer Drug Design 6, 569-584 (1991).
James, Towards gene-inhibition therapy: a review of progress and prospects in the field of antiviral antisense nucleic acids and ribozymes, Antiviral Chemistry & Chemotherapy 2(4), 191-214 (1991).

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