Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Patent
1996-07-19
1998-11-10
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
4352523, 4353201, 435325, 435348, 435419, 536 231, 536 235, C07H 2100, C12Q 121, C12Q 119, C12Q 510
Patent
active
058342982
ABSTRACT:
This invention provides isolated nucleic acid encoding human MAD2, isolated human MAD2 protein. This invention further provides a method of detecting the presence of MAD2 in a tissue sample, a method of determining whether a tumor is susceptible to treatment with a mitotic spindle inhibitor by detecting the presence of MAD2 in the tumor and a method of suppressing tumor formation in a subject which comprises administering the nucleic acid encoding human MAD2 to the subject in an amount effective to enhance expression of MAD2. This invention also provides a nucleic acid reagent capable of detecting the MAD2 gene or gene product and a method for in situ identification of tumors which may be susceptible to treatment with mitotic spindle inhibitors by detecting the absence of nucleic acid encoding MAD2 in the tumor.
REFERENCES:
Woods et al. The construction of a recombinant cDNA library of the poly(a) + mRNA population from normal human lymphocytes. Nucleic Acids Res. 8(22): 5157-5168, 1980.
Traver et al. Rapid screen ing of a human library in yeast artificial chromosomes for single-copy sequences. Proc. Natl. Acad. Sci. USA 86: 5898-5902. 1989.
Sigma Catalog, 1992.
Armstrong, S.A. et al. (1993) J. Biolog. Chem. 268(16):12221-12229.
Li, R., et al. (1993) Nature 366: 82-84.
Brown, M.S. and Goldstein, J.L. (1993) Nature 366:14-15.
Jiang, Y. et al. (1993) Nature 366:84-86.
Elliott George C.
Larson Thomas G.
Sloan-Kettering Institute for Cancer Research
White John P.
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