Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-05-02
2006-05-02
Yu, Misook (Department: 1642)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S325000, C435S320100
Reexamination Certificate
active
07038028
ABSTRACT:
In accordance with the present invention, there are provided a gene encoding the promoter region of a protein p51 which is capable of inducing cell death, and a gene encoding the 5′-untranslated region of p51. These genes are useful in diagnosing and treating diseases including cancer caused by abnormal regulation of cell propagation. Furthermore, in accordance with the present invention, there are provided the antisense DNAs and the antisense RNAs of these genes, nucleic acid probes comprising parts or all of these genes, methods of detecting the above genes of the present invention or analogous genes using the nucleic acid probes, transformants in which the above gene of the present invention has been introduced, and methods of screening drugs using them. These genes are also useful in diagnosing and treating diseases including cancer, etc.
REFERENCES:
patent: 99/50412 (1999-10-01), None
patent: 99/61610 (1999-12-01), None
Darnell et al., (1990, Molecular Cell Biology, 2nd Edition, pp. 344-345 only).
GenBank Acc. No. AQ168656 (Oct. 16, 1998).
Yang et al., (1998, Molecular Cell, vol. 2, pp. 305-316).
GenBank Acc. No. AF124528 (Jan. 4, 2001).
Voet et al., (1990, Biochemistry, John Wiley & Sons, p. 865).
Motonobu Osada et al., “Cloning and functional analysis of human p51, which structurally and functionally resembles p53”, Nature Medicine (1998), vol. 4, No. 7, p. 839-843.
Martin Augustin et al., “Cloning and chromosomal mapping of the human p53-related Ket gene to Chromosome 3q27 and its murine homolog Ket to mouse Chromosome 16”, Mammalian Genome (1998), vol. 9, No. 11, p. 899-902.
Hartwig Schmale et al., “A novel protein with strong homology to the tumor suppressor p53”, Oncogene (1997), vol. 15, No. 11, p. 1363-1367.
Copy of the International Search dated Sep. 26, 2000.
Fujii Hideji
Kagaya Shigehide
Sakai Toshiyuki
Sato Takamichi
Sukenaga Yoshikazu
Nields & Lemack
Oncolys Biopharma Inc.
Toshiyuki Sakai
Yu Misook
LandOfFree
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