Gene encoding outer membrane protein B1 of moraxella catarrhalis

Details Gene encoding outer membrane protein B1 of moraxella catarrhalis Gene encoding outer membrane protein B1 of moraxella catarrhalis

1997-10-14

1999-10-26

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 711, 4353201, 435325, 536 237, C12P 2106, C12P 2104, C12N 1500, C07H 2104

Patent

active

059726571

ABSTRACT:
Nucleotide sequences, derived from Moraxella catarrhalis, which encode one or more epitopes of outer membrane protein B1 are disclosed. Recombinant B1 protein or B1 peptides may be produce by culturing in a medium a host cell genetically engineered to contain and express a nucleotide sequence according to the present invention, and recovering the recombinant protein or peptide from the cultured host cell or culture medium. The nucleotide sequence of the present invention can also be used in molecular diagnostic assays for detecting M. catarrhalis genetic material, and in antigenic compositions for producing B1-specific amino acids.

REFERENCES:
Sethi, et al., "Serum Antibodies to Outer Membrane Proteins of Moraxella catarrhalis in Patients with Bronchiectasis: Identification of OMP B1 as an Important Antigen," 1995, Infection and Immunity, vol. 63. pp. 1516-1520.
Campagnari, et al., "Outer Membrane Protein B1, an Iron-Repressible Protein Conserved in the Outer Membrane of Moraxella catarrhalis, Binds Human Transferrin", Infection abd Immunity, 1996, vol. 64, No. 9, pp. 3920-3924.

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