Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1992-01-13
1993-07-20
Wax, Robert A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351723, 435228, 4353201, 536 232, 536 241, C12N 1555, C12N 1531, C12N 980
Patent
active
052292746
ABSTRACT:
A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and derivatives with a cephalosporin C amidase enzyme of a recited sequence, the DNA encoding said enzyme, and expression thereof in a suitable host, e.g., Bacillus species under the control of a suitable promoter.
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Crawford Mark S.
Finkelstein David B.
Rambosek John A.
Caruso Charles M.
Merck & Co. , Inc.
Speer Raymond M.
Walsh Stephen
Wax Robert A.
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