Gene encoding novel human secretory phospholipase A2

Details Gene encoding novel human secretory phospholipase A2 Gene encoding novel human secretory phospholipase A2

2005-03-29

2005-03-29

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S252300, C435S320100, C536S023200, C530S350000

Reexamination Certificate

active

06872557

ABSTRACT:
This invention relates to a gene encoding human secretory type phospholipase A2(PLA2). According to the invention, an expression vector having this gene, and a transformant having the expression vector are obtainable. The PLA2protein can be produced by the culture of the transformant.

REFERENCES:
patent: 5656602 (1997-08-01), Tseng et al.
Accession No. S17860.*
Accession No. AAR10126.*
Accession No. AAR63055, Accession No. U95301.*
Cupillard et al. [J. Biol. Chem. 272 (25): 15745-15752, Jun. 20 1997].*
J. Balsinde et al.: “Function and Inhibition of Intracellular calcium-independent phospholipase A2” J. Biol. Chem., vol. 272, No. 26, pp. 16069-16072 1997.
J.A. Tischfield et al.: “A reassessment of the low molecular weight phospholipase A2 gene family in mammals” J. Biol. Chem., vol. 272, No. 28, pp. 17247-17250 1997.
Jun Ishizaki et al.: “Cloning and characterization of novel mouse and human secretory phospholipase A2s” Journal of Biological Chemistry, vol. 274, No. 35, pp. 24973-24979.
Y. Yokota et al.: “Suppression of murine endotoxic shock by sPLA2 Inhibitor, indoxam, through group IIA sPLA2-independent mechanisms” Biochimica et Biophysica Acta, vol. 1438, No. 2, pp. 213-222, May 18, 1999.
E.D. Mihelich et al.: “Structure-based design of a new class of anti-inflammatory drugs: secretory phospholipase A2 Inhibitors, SPI” Biochimica et Biophysica Acta, vol. 1441, No. 2-3, pp. 223-228.
E. A. Dennis: “The growing phospholipase A2 supperfamily of signal transduction enzymes”0 Tibs Trends in Biochemical Sciences, vol. 22, No. 1, pp. 1-2 1997.
G. Lambeau et al.: “Receptors for a growing family of secreted phospholipase A2” Trends in Pharmacological Sciences, vol. 20, No. 4, pp. 162-170 Apr. 1999.
Nortiko Suzuki et al.: “Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A2s” Journal of Biological Chemistry, vol. 275, No. 8, pp. 5785-5793 Feb. 25, 2000.

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