Gene encoding mutant L3T4 protein which facilitates HIV infectio

Details Gene encoding mutant L3T4 protein which facilitates HIV infectio Gene encoding mutant L3T4 protein which facilitates HIV infectio

1997-04-15

1999-08-10

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

435455, 435462, 435463, 435 5, 4353201, 435325, 435 691, 424 921, C12N 500, C12N 1500, C12N 1509, C12N 1563

Patent

active

059361387

ABSTRACT:
Disclosed are (1) a DNA sequence encoding a mutant L3T4 protein which, when expressed on the surface of a cell, is capable of facilitating infection of the cell by human immunodeficiency virus; the mutant protein includes at least one amino acid residue substitution or deletion in a segment corresponding to the gp120 binding epitope of a native L3T4 protein so as to increase homology between that segment and its counterpart in a CD4 protein; (2) a murine cell line or strain transfected with such a DNA sequence; and (3) a transgenic mouse susceptible to infection by human immunodeficiency virus.

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