Gene encoding MNR2 and uses thereof

Details Gene encoding MNR2 and uses thereof Gene encoding MNR2 and uses thereof

2007-03-20

2007-03-20

Carlson, Karen Cochrane (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

09820598

ABSTRACT:
This invention provides isolated nucleic acids encoding a motor neuron restricted MNR2 protein, and a homeobox HB9 protein. Also provided are purified MNR2 and HB9 proteins, antibodies recognizing these proteins, transgenic animals expressing these proteins, and functionally equivalent analogs of these proteins. Finally, methods are disclosed for inducing differentiation of somatic motor neurons, and for treating diseases related to the lack of normally functioning motor neurons, neurodegenerative diseases, acute nervous system injury, and neuromuscular disease.

REFERENCES:
patent: 6387656 (2002-05-01), Jessell et al.
patent: 2002/0197678 (2002-12-01), Jessell et al.
patent: WO 0018884 (2000-04-01), None
Ahlgren, U. et al. (1996) “The Morphogenesis of the Pancreatic Mesenchyme Is Uncoupled from That of the Pancreatic Epithelium in IPF1/PDX1-deficient Mice”,Development122:1409-1416 (Exhibit 4).
Ahlgren, U. et al. (1997) “Independent Requirement for ISL1 in Formation of Pancreatic Mesenchyme and Islet Cells”,Nature385:257-260 (Exhibit 5).
Ahlgren, U. et al. (1998) “β-Cell-Specific Inactivation of the MouseIpf1/PdxlGene Results in Loss Of the β-Cell Phenotype And Maturity Onset Diabetes”,Genes&Dev.12:1763-1768 (Exhibit 6).
Aigner, L., et al. (1995) “Overexpression of the Neural Growth-Associated Protein GAP-43 Induces Nerve Sprouting in the Adult Nervous System of Transgenic Mice”,Cell83:269-278 (Exhibit 7).
Anderson, D.J. et al. (1997) “The Determination of the Neuronal Phenotype” inMolecular and Cellular Approaches to Neural Development, eds. Cowan, W.M., Jessell, T.M., and Zipursky, S.L. (Oxford University Press; New York, Oxford), pp. 26-63.
Apelqvist, A., et al. (1997) “Sonic Hedgehog Directs Specialised Mesoderm Differentiation in the Intestine and Pancreas”,Current Biology7:801-804 (Exhibit 8).
Appel, B., (1999) “LIMitless Combinations?”,Neuron22:3-5 (Exhibit 9).
Arber et al. (1999) “Requirement for the Homeobox GeneHb9in the Consolidation of Motor Neuron Identity”,Neuron23:659-674.
Bang, A.G. et al. (1996) “Regulation of Vertebrate Neural Cell Fate by Transcription Factors”,Curr. Opin. Neurobiol.6:25-32.
Barber, R.P. et al. (1991) Generation Patterns of Immunocytochemically Identified Cholinergic Neurons at Autonomic Levels of the Rat Spinal Cord.J. Comp. Neurol.311:509-519 (Exhibit 10).
Basler, K. et al. (1993) “Control of Cell Pattern in the Neural Tube: Regulation of Cell Differentiation by Dorsalin-1, a Novel TGF Beta Family Member”,Cell73:687-702.
Begley, C.G. et al. (1992) “Molecular Characterization ofnscl, a Gene Encoding a Helix-loop-helix Protein Expressed in the Developing Nervous System”,Proc. Natl. Acad. Sci. USA89:38-42.
Bitgood, M.J. et al. (1995) “Hedgehog andBmpGenes Are Coexpressed at Many Diverse Sites of Cell-Cell Interaction in the Mouse Embryo”,Dev. Biol.172:126-138 (Exhibit 11).
Branch, A.D. (1998) “A Good Antisense Molecule Is Hard To Find”,Trends in Biochemical Sciences23: 45-50.
Briscoe, J. et al. (1999) “Homeobox GeneNkx2.2and Specification of Neuronal Identity by Graded Sonic hedgehog Signalling”,Nature398:622-627 (Exhibit 12).
Burke, A.C. et al. (1996) “Virally Mediated Misexpression ofHoxc-6in the Cervical Mesoderm Results in Spinal Nerve Truncations”,Dev. Biol.178:192-197.
Cepko, C.L. (1999) “The Roles of Intrinsic and Extrinsic Cues and bHLH Genes in the Determination of Retinal Cell Fates”,Curr. Opin. Neurobiol9:37-46 (Exhibit 13).
Chen, R. et al. (1997) “Dachshund and Eyes Absent Proteins Form a Complex and Function Synergistically to Induce Ectopic Eye Development in Drosophila”,Cell91:893-903.
Chiang, C. et al. (1996) “Cyclopia and Defective Axial Patterning in Mice Lacking Sonic Hedgehog Gene Function”,Nature383:407-413.
Crook, ed. (1998) inBasic Principles of Antisense Therapeutics(Springer-Verlag; New York), pp. 1 and 4.
Database Tumor Gene Index (Jun. 1998) Accession No. A1560820. NCI-CGAP. National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor Gene Index.
Deguchi et al. (1991) “Nucleotide Sequence of a Novel Diverged Human Homeobox Gene Encodes a DNA Binding Protein”,Nucleic Acids Research19:3742.
Ding, Q. et al. (1998) “Diminished Sonic Hedgehog Signaling and Lack of Floor Plate Differentiation in Gli2 Mutant Mice”,Development125:2533-2543.
Dutta, S. et al. (1998) “Regulatory Factor Linked to Late-Onset Diabetes?”,Nature392:560 (Exhibit 4).
Edlund, H. (1998) “Perspectives in Diabetes: Transcribing Pancreas”,Diabetes47:1817-1823 (Exhibit 15).
Edlund, T. et al. (1999) “Progression from Extrinsic to Intrinsic Signaling in Cell Fate Specification: a View from the Nervous System”,Cell96:211-224 (Exhibit 16).
Ensini, M. et al. (1998) “The Control of Rostrocaudal Pattern in the Developing Spinal Cord: Specification of Motor Neuron Subtype Identity Is Initiated by Signals from Paraxial Mesoderm”,Development125:969-982 (Exhibit 17).
Ericson, J. et al. (1992) “Early Stages of Motor Neuron Differentation Revealed by Expression of Homeobox Gene Islet-1”,Science256:1555-60.
Ericson, J. et al. (1996) “Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity”,Cell87:661-673.
Ericson, J. et al. (1997) “Graded Sonic Hedgehog Signaling and the Specification of Cell Fate in the Ventral Neural Tube”,Cold Spring Harbor Symp. Quant. Biol.62:451-466 (Exhibit 18).
Ericson, J. et al. (1997) “Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling”,Cell90:169-180.
Fedtsova, N. et al. (1997) “Inhibitory Effects of Ventral Signals on the Development of Brn-3.0-expressing Neurons in the Dorsal Spinal Cord”,Dev. Biol.190:18-31.
Goridis, C. (1999) “Transcriptional Control of Neurotransmitter Phenotype”,Curr. Opin. Neurobiol.9:47-53 (Exhibit 19).
Goulding, M. (1998) “Specifying Motor Neurons and Their Connections”,Neuron21:943-946 (Exhibit 20).
Halder, G. et al. (1995) “Introduction of Ectopic Eyes by Targeted Expression of the Eyeless Gene in Drosophila”,Science267:1788-1792.
Harrison, K.A. et al. (1994) “A Novel Human Homeobox Gene Distantly Related to Proboscipedia Is Expressed in Lymphoid and Pancreatic Tissues”,J. Biol. Chem.269:19968-19975.
Hebrok, M. et al. (1998) “Notochord Repression of Endodermal Sonic Hedgehog Permits Pancreas Development”,Genes&Dev.12:1705-1713 (Exhibit 21).
Hynes, M. et al. (1997) “Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1”,Neuron19:15-26.
Ingham, P.W. (1995) “Signaling by Hedgehog Family Proteins inDrosophilaand Vertebrate Development”,Curr. Opin. Genet. Dev.5:492-498.
Jonsson, J. et al. (1994) “Insulin-Promoter-Factor 1 is Required for Pancreas Development in Mice”,Nature371:606-609 (Exhibit 22).
Jurata, L.W. et al. (1998) “The Nuclear LIM Domain Interactor Nli Mediates Homo-and Heterodimerization of Lim Domain Transcription Factors”,J. Biol. Chem.273:3152-3157.
Kalter, H. (1993) “Case Reports of Malformations Associated with Maternal Diabetes: History and Critique”,Clin. Genet.43:174-179 (Exhibit 23).
Kim, S.K. et al. (1997) “Notochord to Endoderm Signaling is Required for Pancreas Development”,Development124:4243-4252 (Exhibit 24).
Krapp, A. et al. (1998) “The bHLH Protein PTF1-p48 is Essential for the Formation of the Exocrine and the Correct Spatial Organization of the Endocrine Pancreas”,Genes&Dev.12:3752-3763 (Exhibit 25).
Lance-Jones, C. et al. (1981) “Pathway Selection by Embryonic Chick Motoneurons in an Experimentally Altered Environment”,Proceedings of the R

Affiliated with

Also associated with

Rating

Gene encoding MNR2 and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gene encoding MNR2 and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene encoding MNR2 and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3751926