Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-07-11
2006-07-11
Schnizer, Richard (Department: 1635)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C536S023500, C424S198100, C435S375000, C435S455000
Reexamination Certificate
active
07074771
ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a motor neuron restricted pattern, MNR2, protein. This invention provides an isolated nucleic acid molecule of at least 15 contiguous nucleotides capable of specifically hybridizing with a unique sequence included within the sequence of the nucleic acid molecule encoding a MNR2 protein. This invention provides a purified MNR2 protein, a polyclonal and monoclonal antibody directed to an epitope of an MNR2 protein. This invention provides a method of inducing differentiation somatic motor neurons which comprises expressing MNR2 protein in any neural progenitor cells. This invention provides a transgenic animal which expresses an MNR2 protein. This invention provides a pharmaceutical composition comprising a MNR2 protein and pharmaceutically acceptable carrier. This invention provides methods of treating subjects afflicted with an abnormality associated with a lack of normally functioning motor neurons, neurodegenerative disease, an acute nervous system injury and a neuromuscular disease which comprises contacting the subject with a pharmaceutical composition comprising a MNR2 protein and pharmaceutically acceptable carrier. This invention provides a functionally equivalent analog of MNR2 that induces or prevents MNR2 differentiation of neural progenitor cells.
REFERENCES:
patent: 6387656 (2002-05-01), Jessell et al.
patent: 2003/0104374 (2003-06-01), Jessell et al.
patent: WO 0018884 (2000-04-01), None
Roelink et al (Cell 81: 445-455), 1995).
Bowie et al (Science 247: 1306-1310, 1990).
Rudinger (In Peptide Hormones J.A. Parsons, Ed. University Park Press, Baltimore, 1976, pp. 1, 6, and 7).
Ngo et al (In The Protein Folding Problem and Tertiary Structure Prediction, K. Merz Jr. and S. Legrand, Eds. Birkhauser, Boston, 1994, pp. 433 and 492-495. ).
Vollmer et al (J. Neurochem. 71(1): 1-19, Jul. 1998).
Hagger (J. Anim. Sci. 70: 2045-2052, 1992).
Anderson, D.J. et al. (1997) The Determination of the Neuronal Phenotype.In Molecular and Cellular Approaches to Neural Development, Eds. Cowan, W.M., Jessell, T.M., and Zipursky, S.L. Oxford University Press, New York, Oxford, pp. 26-63.
Arber et al. (1999) Requirement for the Homeobox Gene Hb9 in the Consolidation of Motor Neuron Identity,Neuron23:659-674.
Bang, A.G. et al. (1996) Regulation of Vertebrate Neural Cell Fate by Transcription Factors,Curr. Opin. Neurobiol.6:25-32.
Basler, K. et al. (1993) Control of Cell Pattern in the Neural Tube: Regulation of Cell Differentiation by Dorsalin-1, a Novel TGF Beta Family Member,Cell73:687-702.
Begley, C.G. et al. (1992) Molecular Characterization of nscl, a Gene Encoding a Helix-loop-helix Protein Expressed in the Developing Nervous System,Proc. Natl. Acad. Sci. USA89:38-42.
Branch.Trends in Biochemical Sciences23: 45-50; 1998.
Burke, A.C. et al. (1996) Virally Mediated Misexpression of Hoxc-6 in the Cervical Mesoderm Results in Spinal Nerve Truncations,Dev. Biol.178:192-197.
Chen, R. et al. (1997) Dachshund and Eyes Absent Proteins Form a Complex and Function Synergistically to Induce Ectopic Eye Development in Drosophila,Cell91:893-903.
Chiang, C. et al. (1996) Cyclopia and Defective Axial Patterning in Mice Lacking Sonic Hedgehog Gene Function,Nature383:407-413.
CrookIn Basic Principles of Antisense Therapeutics, (1998) Springer-Verlag, Eds, New York, pp. 1 and 4.
Database Tumor Gene Index. Accession No. A1560820. NCI-CGAP. National Cancer Institute, Cancer Genome Anatomy Project (CGAP), Tumor Gene Index. Jun. 1998.
Deguchi et al. (1991) Nucleotide Sequence of a Novel Diverged Human Homeobox Gene Encodes a DNA Binding Protein,Nucleic Acids Research19:3742.
Ding, Q. et al. (1998) Diminished Sonic Hedgehog Signaling and Lack of Floor Plate Differentiation in Gli2 Mutant Mice,Development125:2533-2543.
Ericson, J. et al. (1992) Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1,Science256:1555-60.
Ericson, J. et al. (1996) Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity,Cell87:661-673.
Ericson, J. et al. (1997) Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling,Cell90:169-180.
Fedtsova, N. et al. (1997) Inhibitory Effects of Ventral Signals on the Development of Brn-3.0-expressing Neurons in the Dorsal Spinal Cord,Dev. Biol.190:18-31.
Halder, G. et al. (1995) Induction of Ectopic Eyes by Targeted Expression of the Eyeless Gene inDrosophila, Science267:1788-1792.
Harrison, K.A. et al. (1994) a Novel Human Homeobox Gene Distantly Related to Proboscipedia Is Expressed in Lymphoid and Pancreatic Tissues,The Journal of Biological Chemistry269:19968-19975.
Hynes, M. et al. (1997) Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1,Neuron19:15-26.
Ingham, P.W. (1995) Signaling by Hedgehog Family Proteins inDrosophilaand Vertebrate Development,Curr. Opin. Genet. Dev.5:492-498.
Jurata, L.W. et al. (1998) the Nuclear Lim Domain Interactor Nli Mediates Homo-and Heterodimerization of Lim Domain Transcription Factors,J. Biol. Chem.273:3152-3157.
Langman, J. et al. (1966) Behavior of Neuroepithelial Cells During Closure of the Neural Tube,J. Comp. Neurol.127:399-411.
Leber, S.M. and Sanes, J.R. (1995) Migratory Paths of Neurons and Glia in the Embryonic Chick Spinal Cord,J. Neurosci.15:1236-1248.
Lee, J. et al. (1997) Gli1 Is a Target of Sonic Hedgehog That Induces Ventral Neural Tube Development,Development124:2537-2552.
Liem, K.F. et al. (1997) A Role for the Roof Plate and its Resident TGFbeta-related Proteins in Neuronal Patterning in the Dorsal Spinal Cord,Cell91:127-138.
Lo, L. et al. (1998) MASH1 Activates Expression of the Paired Homeodomain Transcription Factor Phox2a, and Couples Pan-neuronal and Subtype-specific Components of Autonomic Neuronal Identity,Development125:609-620.
Lumsden, A. et al. (1996) Patterning the Vertebrate Neuraxis,Science274:1109-1115.
Marti, E. et al. (1995) Requirement of 19k Form of Sonic Hedgehog for Induction of Distinct Ventral Cell Types,Nature375:322-325.
Matise M.P. et al. (1998) Gli2 Is Required for Induction of Floor Plate and Adjacent Cells, but Not Most Ventral Neurons in the Mouse Central Nervous System,Development125:2759-2770.
Osumi, N. et al. (1997) Pax-6 Is Involved in Specification of the Hindbrain Motor Neuron Subtype,Development124:2961-2972.
Pabst, O. et al. (1998) Nkx2-9 Is a Novel Homeobox Transcription Factor Which Demarcates Ventral Domains in the Developing Mouse CNS,Mech. Dev.73:85-93.
Pattyn, A. et al. (1997) Expression and Interactions of the Two Closely Related Homeobox Genes Phox2a and Phox2b During Neurogenesis,Development124: 4065-4075.
Pfaff, S. L. et al. (1996) Requirement for LIM Homeobox Gene Isl1 in Motor Neuron Generation Reveals a Motor Neuron-dependent Step in Interneuron Differentiation,Cell84:309-320.
Pfaff, S. et al. (1998) Neuronal Diversification: Development of Motor Neuron Subtypes,Curr. Opin. Neurobiol.8:27-36.
Pharmacia Biotech catalogue (1995) p. 277.
Pharmacia Biotech catalogue (1995) pp. 104-111.
Pignoni, F. et al. (1997) The Eye-Specification Proteins So and Eya Form a Complex and Regulate Multiple Steps in Drosophila Eye Development,Cell91:881-891.
Riddle, R.D. et al. (1995) Induction Of the LIM Homeobox Gene Lmx1 by WNT7a Establishes Dorsoventral Pattern in the Vertebrate Limb,Cell83:631-640.
Roelink, H. et al. (1995) Floor Plate and Motor Neuron Induction by Different Concentrations of the Amino-Terminal Cleavage Product of Sonic Hedgehog Autoproteolysis,Cell81:445-455.
Roztocil, T. et al. (1997) NeuroM, a Neural Helix-loop-helix Transcription Factor, Defines a New Transition Stage in Neurogenesis,Development124:3263-3272.
Ruiz i Altaba et al. (1993) Ectopic Neural Expression of a Floor Plate Marker in Frog Embryos Injected with the Midline Transcription Factor Pintallavis,Proc. Natl. Acad. Sci. USA90:8268-8272.
Ruiz i Altaba et al. (1995) Restrictions to Floor Plate Induction by Hedgehog and Winged-helix Genes in the Neural Tube of Frog Embryos,Mol. Cell Neurosc
Jessell Thomas M.
Tanabe Yasuto
William Christopher
Cooper & Dunham LLP
Schnizer Richard
The Trustees of Columbia University in the City of New York
White, Esq. John P.
LandOfFree
Gene encoding MNR2 and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene encoding MNR2 and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene encoding MNR2 and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3557510