Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1995-06-06
1998-11-03
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4353201, 435419, 435325, 435199, 536 232, C12N 922, C12N 1555
Patent
active
058307443
ABSTRACT:
A human DNase polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating bronchopulmonary conditions. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
REFERENCES:
patent: 5279823 (1994-01-01), Frenz et al.
Ito, K. et al., J. Biochem., 95(5):1399-1406 (1984).
Funakoshi, A., et al., J. Biochem., 82(6):1771-1777 (1977).
Shields, D., Biochemical Society Transactions, 16:195-196 (1988).
Pergolizzi et al, Gene, v. 168, pp. 267-270, 1996.
Parrish et al., Human Molecular Genetics, 1995, 4(9): 1557-1564.
Adams Mark D.
Rosen Craig A.
Ruben Steven M.
Hendricks Keith D.
Human Genome Sciences Inc.
Mullins J. G.
Olstein Elliot M.
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