Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1996-10-10
1999-07-27
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 536 221, 536 231, 536 237, 435 691, 435 693, A61K 39102, C07H 1900, C07H 2102, C07H 2104
Patent
active
059286512
ABSTRACT:
High molecular weight surface proteins of non-typeable Haemophilus influenzae which exhibit immunogenic properties and genes encoding the same are described. Specifically, genes coding for two immunodominant high molecular weight proteins, HMW1 and HMW2, have been cloned, expressed and sequenced, while genes coding for high molecular proteins HKW3 and HMW4 have been cloned, expressed and partially sequenced.
REFERENCES:
Pediatric Infectious Disease Journal, vol. 9, No. 5, issued May 1990, S.J. Barenkamp et al., "Development of Serum Bactericidal Activity Following Nontypable Haemophilus influenzae Acute Otitis Media", pp. 333-339, see entire document.
Journal of Clinical Microbiology, vol. 29, No. 11, issued Nov. 1991, A.C. Caputa et al., "110 Kilodalton Recombinant Protein which is Immunoreactive with Sera from Humans, Dogs, and Horses with Lyme Borreliosis", pp. 2418-2423, see entire document.
Joint Meeting of the American Pediatric Society and the Society for Pediatric Research, May 07-10, 1990, S.J. Barenkamp, "Cloning and Expression of Genes for Nontypable Haemophilus influenzae (NTHI) High Molecular Weight (HMW) Outer Membrane Proteins which are Targets of Bactericidal Antibody", Abstract 983, Pediatric Research, vol. 27, (4 part 2).
The Journal of Infectious Diseases, vol. 165 (Suppl.), issued Aug. 1992, S.J.Barenkamp, "Outer Membrane Protein and Lipopolysaccharides of Nontypeable Haemophilus influenzae", pp. S181 -S184, see entire document.
Infection and Immunity, vol. 60(4), issued Apr. 1992, S.J.Barenkamp et al, Cloning, Expression and DNA Sequence Analysis of Genes Encoding Nontypable Haemophilus influenzae High-Molecular-Weight Surface-Exposed Proteins Related to Filamentous Hemagglutinin of Bordetella pertussis pp. 1302-1313, see entire document.
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Pediatr. Infect. Dis. J., 9: 333-339, 1990, Stephen J. Barenkamp and Frank F. Bodor, "Development of Serum Bacterial Activity Following Nontypable Haemophilus influenzae Acute Otitis Media".
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Sidberry Hazel F.
St. Louis University
Washington University
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