Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-05-14
1994-05-24
Hill, Jr., Robert J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
4353201, 435 691, C07H 1512, C12N 1500
Patent
active
053150007
ABSTRACT:
A growth factor protein similar in structure and function to hepatocyte growth factor has been discovered along with the DNA and cDNA coding for this in both the mouse and human. The DNA includes 18 exons and is homologous to DNA at the D3F15S2 locus on human chromosome 3; a region predicted to code for one or more tumor suppressor genes.
REFERENCES:
Harbour et al. "Expression in Lung Cancer of a Trnscribed Sequence at the DNF 1552 Locus at Chromosome 3p21 "Anticancer Research 10 23-28 (1990).
Naylor et al. "Loss of heterozygosity of Chromosome 3p markers in small-cell using cancer" Nature 329 451-454 (1987).
Naylor et al "The DNF15S2 Locus at 3p21 Is Transcribed in Normal and Small Cell Lung Cancer," Genomics 4 355-361 (1989).
S. Degen: Isolation & Characterization of the Human Prothrombin Gene & Related Genes, Doctoral Thesis by S. Degen (1982).
S. Degen et al; Characterization of the Mouse cDNA & Gene Coding for a Hepatocyte Growth Factor-like Protein: Expression during Development; Biochemistry, 1991, 30 (pp. 9781-9791).
S. Han et al; Characterization of the DNF15S2 Locus on Human Chromosome 3: Identification of a Gene Coding for Four Kringle Domains with Homology to Hepatocyte Growth Factor, Biochemistry, 1991, 30 (pp. 9768-9780).
Michalopoulos et al: Hepatocyte Growth Factor, Hepatology vol. 15, No. 1, 1992, pp. 149-155.
Fausto et al: Regulation of Liver Growth: Protooncogens & Transforming Growth Factors; Laboratory Investigation, vol. 60, No. 1, p. 4, 1989.
Michalopoulos; Liver Regeneration: Molecular Mechanisms of Growth Control; The FASEB Journal, vol. 4, Feb. 1990.
Fusto: Liver Regeneration; ASLD Meeting 1991, pp. 149-160.
A. Skeel et al: Macrophage Stimulating Protein: Purification, Parttial Amino Acid Sequence, & Cellular Activity; The Journal of Experimental Medicine, vol. 173, May, 1991, 1227-1234.
Fausto: Hepatocyte Growth Factor Receptor & The c-Met Oncogene Abstract; Hepatology, vol. 14, No. 4, Pt. 1, 1991, pp. 738-740.
Cermak Shelly Guest
Children's Hospital Medical Center
Hill Jr. Robert J.
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