Gene encoding brain-specific membrane protein

Details Gene encoding brain-specific membrane protein Gene encoding brain-specific membrane protein

2005-02-08

2005-02-08

Kunz, Gary (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S395000

Reexamination Certificate

active

06852836

ABSTRACT:
A novel gene apparently encoding a transmembrane glycoprotein has been successfully isolated by constructing a cDNA library of 4 kb or above in size from mRNA expressed in human adult brain and analyzing the structures of cDNAs contained within said library by the shotgun method. The novel gene shows brain-specific expression and the protein encoded by said gene has a typical PDZ protein binding motif.

REFERENCES:
Adams et al., “Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library”, Nature Genetics, 4:374-380, 1993.
Dong et al., “GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors”, Nature, 386:279-284, 1997.
Nagase et al., “Prediction of the Coding Sequences of Unidentified Human Genes. XV. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro”, DNA Res., 6:337-345, 1999.
Poulat et al., “The Human Testis Determining FactorSRYBinds a Nuclear Factor Containing PDZ Protein Interaction Domans”, J. Biol. Chem., 272(11):7167-7172, 1997.

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