Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-05-31
2011-05-31
Spector, Lorraine (Department: 1649)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S320100, C435S325000
Reexamination Certificate
active
07951928
ABSTRACT:
To provide a novel protein that can be a preventive/remedy in neurodegenerative diseases such as polyglutamine diseases based on the finding obtained by revealing the relationship between transcriptional dysfunction and neuronal death. Disclosed is a protein that is one of the following proteins (a) and (b).(a) A protein including an amino acid sequence represented by any one of SEQ ID NOS: 1 to 3.(b) A protein including an amino acid sequence in which one to several amino acids are deleted, substituted or added in the amino acid sequence of (a), the protein having a dominant negative effect on a transcriptional activation factor YAP.
REFERENCES:
patent: 6022740 (2000-02-01), Sudol et al.
patent: 6495376 (2002-12-01), Lu et al.
patent: 2003/0119009 (2003-06-01), Stuart et al.
patent: 2002-541065 (2002-12-01), None
patent: 00/48621 (2000-08-01), None
Sudol, M., et al., Characterization of the Mammalian YAP (Yes-associated Protein) Gene and Its Role in Defining a Novel Protein Module, the WW Domain, J. Biol. Chem., vol. 270, No. 24, Jun. 16, 1995, p. 14733-14741.
Vassilev, A, et al., TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm, Genes Dev., May 15, 2001, vol. 15, No. 10, p. 1229-1241.
Basu, S., et al., Akt Phosphorylates the Yes-Associated Protein, YAP, to Induce Interaction with 14-3-3 and Attenuation of p73-Mediated Apoptosis, Mol. Cell, Jan. 2003, vol. 11, No. 1, p. 11-23.
Hoshino, M., et al., General transcriptional repression by polyglutamine disease proteins is not directly linked to the presence of inclusion bodies, Biochem. Biophys. Res. Commun., Jan. 2, 2004,vol. 313, No. 1, p. 110-116.
Okazawa, H., Polyglutamine diseases: a transcription disorder?, Cell. Mol. Life Sci, Jul. 2003, vol. 60, No. 7, p. 1427-1439.
McCampbell, A, et al., Histone deacetylase inhibitors reduce polyglutamine toxicity, Proc. Natl. Acad. Sci. USA, Dec. 18, 2001, vol. 98, No. 26, p. 15179-15184.
Igarashi, S., et al., Search for polyglutamine disease genes by candidate gene approach, Protein, Nucleic acid and Enzyme, Dec. 10, 2001, vol. 46, No. 16, p. 2295-2298.
Hoshino, M., et al., Gene expression profile change by transcriptional suppression in primary culture neurons: a model of polyglutamine diseases, Bulletin of the Japanese Society for Neurochemistry, Aug. 10, 2004, vol. 43, No. 2/3, p. 542.
Hoshino, M., et al., Changes in gene expression following transcriptional suppression by alpha-amanitin treatment of primary culture neurons: A model of polyglutamine diseases, Neuropathology, Jun. 2005, vol. 25, No. 2, p. A21.
Komuro Akihiko et al, “WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus,” The Journal of Biological Chemistry, Aug. 29, 2003, vol. 278, No. 35, pp. 33334-33341.
Yagi, Ryohei et al, “A WW domain-containing Yes-associated protein (YAP) is a novel transcriptional co-activator,” The EMBO Journal, May 4, 1999, vol. 18, No. 9, pp. 2551-2562.
Database EMBL, Oct. 8, 2001, “Mus musculus yes-associated protein 1, mRNA (cDNA clone MGC:25351 Image:4239820), complete cds.” Retrieved From EBI accession No. EMBL:BC014733.
Carmody & Torrance LLP
MacFarlane Stacey
Spector Lorraine
Tokyo Medical and Dental University
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