Gene encoding a nonribosomal peptide synthetase for the...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023200, C435S069100, C435S320100, C435S252300, C435S254110, C435S325000, C435S419000, C530S350000

Reexamination Certificate

active

07635765

ABSTRACT:
The present invention relates to isolated genetic sequences encoding nonribosomal peptide synthetase (NRPS) proteins which direct the biosynthesis of the antibiotic ramoplanin in microorganisms such asActinoplanessp. The isolated gene sequences serve as substrates for bioengineering of antibiotic structures.

REFERENCES:
patent: 4303646 (1981-12-01), Cavalleri et al.
patent: 4427656 (1984-01-01), Cavalleri et al.
patent: 4551433 (1985-11-01), DeBoer
patent: 5017478 (1991-05-01), Cashion et al.
patent: 7078185 (2006-07-01), Farnet et al.
Ciabatti R. et al., J. Antibiot (Tokyo), (1989)vol. 42, No. 2, pp. 254-267 “Ramoplanin (A-16686), a new glycolipodepsipeptide antibiotic. III. Structure elucidation”.
Gastaldo I. et al., J. Ind. Microbiol. (1992), vol. 11, No. 1, pp. 13-18 “Isolation, structure determination and biological activity of A-16686 factors A′1, A′2 and A′3 glycodepsipeptide antibiotics”.
Konz D. & Marahiel MA, Chem. Biol. (1999) vol. 6, pp. R39-R48 “How do peptide synthetases generate structural diversity?”.
Quadri LE et al., Chem. Biol. (1998) vol. 5, No. 11, pp. 631-645 “Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin”.
Chung S. K. et al., The Journal of Antibiotics (1986) pp. 642-651 “Biosynthetic Studies of Aridicin Antibiotics—1. Labeling patterns and overall pathways”.
Nicas T. et al., Biotechnology of Antibiotics, Marcel Dekker, Inc. (1997) pp. 363-392 “Vancomycin and other glycopeptides”.
Bateman Alex et al. Nucleic Acid Research (2000) vol. 28, No. 1, pp. 263-266 “The Pfam protein families database”.
Ullah JH et al., J. Mol Biol. (1998)vol. 284, No. 1, pp. 125-136 “The crystal structure of the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia at 1.7 A resolution”.
Stryer, Biochemistry 3rd edition (1998), W.H. Freeman and Co., New York, pp. 752-754.
Casey & Davidson, Nucl. Acid. Res. (1977) vol. 4, No. 5, pp. 1539-1552 “Rates of formation and thermal stabilities of RNA:DNA and DNA:RNA duplexes at high concentrations of formamide”.
Edge MD, Nature (1981) vol. 20, No. 292, pp. 756-762 “Total synthesis of a human leukocyte interferon gene”.
Namblar KP et al., Science (1984) vol. 23, No. 233, pp. 1299-1301 “Total synthesis and cloning of a gene coding for the ribonuclease S protein”.
Jay E. et al., J. Biol. Chem. (1984) vol. 259, No. 10, pp. 6311-6317 “Chemical Synthesis of a Biologically Active Gene for Human Immune Interferon-γ”.
Malpartida F. and Hopwood DA, Nature (1984) vol. 6, No. 309, pp. 462-464 “Molecular cloning of the whole biosynthestic pathway of aStreptomycesantibitic and its expression in a heterologous host”.
Kao CM et al., Science (1994) vol. 22, No. 265, pp. 509-512 “Engineered biosyntesis of complete macrolactone in a heterologous host”.
Hopwood DA et al., Methods Enzymol. (1987) vol. 153, pp. 116-166 “Plasmid and phage vectors for gene cloning and analysis inStreptomyces”.
Vara J. et al., J. Bacteriol. (1989) vol. 171, No. 11, pp. 5872-5881 “Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway inSaccharopolyspora erythraea”.
Guilfoile P. & Hutchinson R., Proc. Natl. Acad. Sci. USA (1991) vol. 88, pp. 8553-8557 “A bacterial analog of the mdr gene of mammalian tumor cells in present inStreptomyces peucetius, the producer of daunorubicin and doxorubicin”.
Shen B. and Hutchinson R., J. Biol. Chem. (1994) vol. 269, No. 48, pp. 30726-30733 “Triple hydroxylation of tetracenomycin A2 to tetracenomycin C inStreptomyces glausescens”.
Pieper R. et al., Nature (1995) vol. 16, No. 378, pp. 263-266 “Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases”.
Pieper R. et al., J. Am. Chem. Soc. (1995) vol. 117, pp. 11373-11374 “Remarkably broad substrate specofoty of a modular polyketide synthase in a cell-free system”.
Wiesmann KE et al., Chem. Biol. (1995) vol. 2, No. 9, pp. 583-589 “Polyketide synthesis in vitro on a modular polyketide synthase”.
Stutzman-Engwall K. and Hutchison R. , Proc. Ntl. Acad. Sci. USA (1989) vol. 86, pp. 3135-3139 “Multigene families for anthracycline antibiotic production inStreptomyces peucetius”.
Motamedi H. and Hutchinson R., Proc. Ntl. Acad. Sci. USA (1987) vol. 84, pp. 4445-4449 “Cloning and heterologous expression of a gene cluster for the biosynthesis of tetracenomycin C, the anthracycline antitumor antibiotic ofStreptomyces glaucescens”.
Grimm A. et al., Gene (1994) vol. 151, pp. 1-10 “Characterization of theStreptomyces peucetiusATCC 29050 genes encoding doxorubin polyketide synthase”.
van Wageningen AMA et al., Chem. Biol. (1997) vol. 5, pp. 155-162 “Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group of antibiotic”.
Hofmann K. et al., Nucleic Acids Research (1999) vol. 27, No. 1, pp. 215-219 “The PROSITE database, its status in 1999”.
Osoegawa K. et al., Genomics (1998) vol. 15, No. 52, pp. 1-8 “An improved approached for construction of bacterial artificial chromosome librairies”.
Huang Z. et al., Nucl. Acids Res. (1996) vol. 24, No. 21, pp. 4202-4209 “Large DNA fragment sizing by flow cytometry: application to the characterization of P1 artificial chromosomes (PAC) clones”.
Quadri LE et al., Biochemistry (1998) vol. 10, No. 37, pp 1585-1595 “Characterization of Sfp, aBacillus subtillsphosphopantheinyl transferase for peptidyl carrier protein domains in peptide synthetases”.
Nakano MM et al., Mol. Gen. Genet. (1992) vol. 232, No. 2, pp. 313-321 “Isolation and characterization of sfp: a gene that functions in the production of the lipopeptide biosurfactant, surfactin, inBacillus subtilis”.
Kunkel T. et al., Proc. Natl. Acad. Sci. USA (1985) vol. 82, pp. 448-492 “Rapid and efficient site-specofoc mutagenesis without phenotypic selection”.
Carreras CW and Khosia C, Biochemistry (1998) vol. 24, No. 37, pp. 2084-2088 “Purification and in vitro reconstitution of the essential protein components of an aromatic polyketide synthase”.
Hosoda J. et al, Agric. Biol. Chem. (1977) vol. 41, No. 10, pp. 2007-2012 “Incorporation of 14C-Amino Acids into Nocardin A by growing cells”.
Nielsen PE et al., Science (1991) vol. 6, No. 254, pp. 1497-1500 “Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide”.
Southern EM, J. Mol. Biol. (1975) vol. 5, No. 98, pp. 503-517 “Detection of specific sequences among DNA fragments seperated by gel electrophoresis”.
Dunn AR et al., Cell (1977) vol. 12, No. 1, pp. 23-36 “A novel method to map transcripts: evidence for homology between an adenovirus mRNA and discrete multiple regions of the viral genome”.
Altschul SF et al., J. Mol. Biol. (1990) vol. 5, 215, pp. 403-410 “Basic local alignment search tool”.
Fleishmann RD et al., Science (1995) vol. 28, No. 269, pp. 496-512 “Whole-genome random sequencing and assembly ofHaemophilus influenzaRd.”
Altschul S. et al., Nucleic Acids Res. (1997) vol. 25, No. 17, pp. 3389-3402 “Grapped BLAST and PSI-BLAST: a new generation of protein database search programs”.
Hammond J. S. et al., J. Chem. Soc., Chem Commun. (1982), pp. 344-346 “On the biosynthesis of the antibiotic vancomycin”.
Stachelhaus T. et al., Chem. Biol. (1999) vol. 6, No. 8, pp. 493-505 “The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases”.
Challis G. et al., Chem. Biol. (2000) vol. 7, pp. 211-224 “Predictive, structure-based model of amino acid recognition by non-ribosomal peptide synthet

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Gene encoding a nonribosomal peptide synthetase for the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gene encoding a nonribosomal peptide synthetase for the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene encoding a nonribosomal peptide synthetase for the... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4093537

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.