Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-11-19
2011-12-13
Canella, Karen (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S325000, C435S366000
Reexamination Certificate
active
08076091
ABSTRACT:
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
REFERENCES:
patent: 5399483 (1995-03-01), Shibano et al.
patent: 5434075 (1995-07-01), Mechetner et al.
patent: 5612185 (1997-03-01), Uhr et al.
patent: 6008002 (1999-12-01), Bodey
patent: 6846883 (2005-01-01), Frank et al.
patent: 7465554 (2008-12-01), Frank et al.
patent: 7928202 (2011-04-01), Frank et al.
patent: 2008/0003206 (2008-01-01), Frank
patent: 2009/0117117 (2009-05-01), Frank et al.
patent: 0 174 810 (1986-03-01), None
patent: 0 267 781 (1988-05-01), None
patent: WO 93/25700 (1993-12-01), None
patent: WO 01/94400 (2001-12-01), None
patent: WO 02/40541 (2002-05-01), None
Guerci et al., 1995, Blood, vol. 85, pp. 2147-2153.
GENBANK Submission; NIH/NCBI, Accession No. AY234788; Frank et al.; Nov. 17, 2003.
Gillet et al., Chemotherapy-induced resistance by ATP-binding cassette transporter genes. Biochim Biophys Acta. Jun. 2007;1775(2):237-62. Epub Jun. 6, 2007.
Mechetner et al., Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A. Jul. 1, 1992;89(13):5824-8.
GENBANK submission; NIH/NCBI; Accession No. AC005060; Waterston; Jun. 12, 1998.
GENBANK submission; NIH/NCBI; Accession No. AC005060; Sulston; Nov. 23, 2009.
EMBL/GENBANK submission; NIH/NCBI; Accession No. O14573; Kalicki; Mar. 1, 2002.
Goodell et al., Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med. Apr. 1, 1996;183(4):1797-806.
Menke et al., Expression analysis of multidrug efflux pump genes in mouse hematopoietic stem and progenitor cells. Blood. 1999;94(10)(Supp 1, Part 1):Abstract #132.
Miwa et al., Biological characteristics of CD7(+) acute leukemia. Leuk Lymphoma. Apr. 1996;21(3-4):239-44.
Spangrude et al., Two mechanisms of discrimination between stem cells and progenitors by rhodamine-123: Mitochondrial activation and multi-drug resistance. Blood. 1995;86(1)(Supp 1):Abstract #1830.
Storms et al., Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity. Proc Natl Acad Sci U S A. Aug. 3, 1999;96(16):9118-23.
Bork, “Powers and Pitfalls in Sequence Analysis: The 70% Hurdle,” Genome Res. 10:398-400 (2000).
Bork et al., “Go Hunting in Sequence Databases But Watch Out for Traps,” Trends in Genetics 12:425-427 (1996).
Bowie et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions,” Science 247: 1306-1311 (1990).
Brenner, “Errors in Genome Annotation,” Trends in Genetics 15:132-133 (1999).
Burgess et al., “Possible Dissociation of the Heparin-Binding and Mitogenic Activities of Heparin-Binding (Acidic Fibroblast) Growth Factor-1 from Its Receptor-Binding Activities by Site-Directed Mutagenesis of a Single Lysine Residue,” J. Cell Biol. 111:2129-2138 (1990).
Dermer, “Another Anniversary for the War on Cancer,” Bio/Technology 12:320 (1994).
Doerks, et al., “Protein Annotation: Detective Work for Function Prediction,” Trends in Genetics 14:248-250 (1998).
Frank, et al., “Regulation of Progenitor Cell Fusion by ABCB5 P-Glycoprotein, a Novel Human ATP-Binding Cassette Transporter,” J. Biol. Chem. 278:47156-47165 (2003).
Frank, N.Y., et al. 2005 “ABCB5-Mediated Doxorubicin Transport and Chemoresistance in Human Malignant Melanoma,” Cancer Res. 60: (10): 4320-4333.
Freshney, “Culture of Animal Cells, A Manual of Basic Technique,” Alan R. Liss, Inc., 1983, New York, p. 4.
Georges et al, “Detection of P-Glycoprotein Isoforms by Gene-Specific Monoclonal Antibodies,” Proc. Natl. Acad, Sci. USA 87: 152-156 (1990).
International Search Report—PCT/US01/18032, dated May 13, 2002.
Kalicki et al., “The Sequence ofH. sapiensBAC Clone CTA-367017,” EMBL/GenBank/DDBJ Databases (Abstract) (1997).
Knutsen, et al., “Cytogenetic and Molecular Characterization of Random Chromosomal Rearrangements Activating the Drug Resistance Gene, MDRI/P-Glycoprotein, in Drug-Selected Cell Lines and Patients with Drug Refractory ALL,” Genes, Chromosomes & Cancer 23:44-54 (1998).
Lazar et al., “Transforming Growth Factor α: Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities,” Molecular and Cellular Biology 8: 1247-1251 (1988).
Mickley, et al., Gene Rearrangement: A Novel Mechanism for MDR-1 Gene Activation,: J. Clin. Invest. 99: 1947-1957 (1997).
Schoenlein, et al., “Double Minute Chromosomes Carrying the Human Multidrug Resistance 1 and 2 Genes are Generated from the Dimerization of Submicroscopic Circular DNAs in Colchicine-Selected KB Carcinoma Cells,” Molec.Biol. of the Cell 3:507-520 (1992).
Scott, et al., “The Pendred Syndrome Gene Codes a Chloride-Iodide Transport Protein,” Nature Genomics 21: 440-443, Nature Genetics, 1999, vol. 22, pp. 440-443.
Skolnick et al., “From Genes to Protein Structure and Function: Novel Applications of Computational Approaches in the Genomic Era,” Trends in Biotech 18:34-39 (2000).
Smith et al., “The Challenges of Genome Sequence Annotation or The Devil is in the Details,” Nature Biotechnology 15: 1222-1223 (1997).
Sequence Comparison cited in U.S. Appl. No. 09/873,409 (Apr. 20, 2003 Office Action).
Sequence Comparison cited in U.S. Appl. No. 09/973,409 (Dec. 31, 2003 Office Action).
Robert, Multidrug resistance in oncology: diagnostic and therapeutic approaches. Eur J Clin Invest. Jun. 1999;29(6):536-45.
Chaudhary et al., Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell. Jul. 12, 1991;66(1):85-94.
Frank Markus H.
Sayegh Mohamed H.
Canella Karen
The Brigham and Women's Hospital, Inc.
Wolf Greenfield & Sacks P.C.
LandOfFree
Gene encoding a multidrug-resistance human P-glycoprotein... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene encoding a multidrug-resistance human P-glycoprotein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene encoding a multidrug-resistance human P-glycoprotein... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4305914