Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2004-09-29
2008-12-16
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S501000, C436S518000
Reexamination Certificate
active
07465554
ABSTRACT:
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in methods for assessing cancer cell susceptibility to therapies directed against multidrug resistance, and for the design of diagnostic and therapeutic methods relating to cancer multidrug resistance. The invention also relates to methods for determining whether a test compound may inhibit multidrug resistance.
REFERENCES:
patent: 5399483 (1995-03-01), Shibano et al.
patent: 6846883 (2005-01-01), Frank et al.
patent: 0 174 810 (1986-03-01), None
patent: 0 267 781 (1988-05-01), None
Bork, “Powers and Pitfalls in Sequence Analysis: The 70% Hurdle,”Genome Res. 10:398-400 (2000).
Bork, et al., “Go Hunting in Sequence Databases But Watch Out for Traps,”Trends in Genetics 12:425-427 (1996).
Bowie, et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions,”Science 247:1306-1311 (1990).
Brenner, “Errors in Genome Annotation,”Trends in Genetics 15:132-133 (1999).
Burgess, et al., “Possible Dissociation of the Heparin-Binding and Mitogenic Activities of Heparin-Binding (Acidic Fibroblast) Growth Factor-1 from Its Receptor-Binding Activities by Site-Directed Mutagenesis of a Single Lysine Residue,”J. Cell. Biol. 111:2129-2138 (1990).
Dermer, “Another Anniversary for the War on Cancer,”Bio/Technology12:320 (1994).
Doerks, et al., “Protein Annotation: Detective Work for Function Prediction,”Trends in Genetics 14:248-250 (1998).
Frank, et al., “Regulation of Progenitor Cell Fusion by ABCB5 P-Glycoprotein, a Novel Human ATP-Binding Cassette Transporter,”J. Biol. Chem. 278:47156-47165 (2003).
Freshney,Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4.
Georges, et al., “Detection of P-Glycoprotein Isoforms by Gene-Specific Monoclonal Antibodies,”Proc. Natl. Acad. Sci. USA 87:152-156 (1990).
Kalicki, et al., “The Sequence ofH. sapiensBAC Clone CTA-367017,” EMBL/GenBank/DDBJ Databases (Abstract) (1997).
Knutsen, et al., “Cytogenetic and Molecular Characterization of Random Chromosomal Rearrangements Activating the Drug Resistance Gene,MDRI/P-Glycoprotein, in Drug-Selected Cell Lines and Patients with Drug Refractory ALL,”Genes, Chromosomes&Cancer 23:44-54 (1998).
Lazar, et al., “Transforming Growth Factor α : Mutation of Aspartic Acid 47 and Leucine 48 Results in Different Biological Activities,”Molecular and Cellular Biology 8:1247-1251 (1988).
Mickley, et al., “Gene Rearrangement: A Novel Mechanism forMDR-1Gene Activation,”J. Clin. Invest. 99:1947-1957 (1997).
Schoenlein, et al., “Double Minute Chromosomes Carrying the Human Multidrug Resistance 1 and 2 Genes are Generated from the Dimerization of Submicroscopic Circular DNAs in Colchicine-Selected KB Carcinoma Cells,”Molec. Biol. of the Cell 3:507-520 (1992).
Scott, et al., “The Pendred Syndrome Gene Codes a Chloride-Iodide Transport Protein,”Nature Genomics 21:440-443 (1999).
Skolnick, et al., “From Genes to Protein Structure and Function: Novel Applications of Computational Approaches in the Genomic Era,”Trends in Biotech. 18:34-39 (2000).
Smith, et al., “The Challenges of Genome Sequence Annotation or ‘The Devil Is in the Details,’”Nature Biotechnology 15:1222-1223 (1997).
Sequence Comparison cited in parent U.S. Appl. No. 09/873,409 (Apr. 20, 2003 Office Action).
Sequence Comparison cited in parent U.S. Appl. No. 09/873,409 (Dec. 31, 2003 Office Action).
Frank, N. Y. et al., 2005, “ABCB5-Mediated Doxorubicin Transport and Chemoresistance in Human Malignant Melanoma,” Cancer Res, 60: (10): 4320-4333.
International Search Report—PCT/US01/18032, dated May 13, 2002.
Frank Markus H.
Sayegh Mohamed H.
The Brigham and Women's Hospital, Inc.
Wolf Greenfield & Sacks P.C.
Yu Misook
LandOfFree
Gene encoding a multidrug-resistance human P-glycoprotein... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gene encoding a multidrug-resistance human P-glycoprotein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gene encoding a multidrug-resistance human P-glycoprotein... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4051726