Gene encoding a DNA repair enzyme and methods of use thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S001110, C536S018700, C536S022100, C536S023100, C536S023500, C435S089000, C435S091100, C435S091400, C435S325000

Reexamination Certificate

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07491807

ABSTRACT:
An isolated nucleic acid molecule encoding a human DNA repair enzyme, MED1, is disclosed. Like other mismatch repair genes which are mutated in certain cancers, MED1, encoding nucleic acids, proteins and antibodies thereto may be used to advantage in genetic or cancer screening assays. MED1, which recognizes and cleaves DNA, may also be used for the diagnostic detection of mutations and genetic variants.

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