Gene encoding 2,3-dihydroxybenzoic acid decarboxylase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Lyase

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4353201, 4352523, 435 911, 435325, 536 231, 536 232, 536 235, C12N 988, C12N 1500, C12N 120, C12N 500, C12P 1934

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060430761

ABSTRACT:
The enzyme 2,3-dihydroxybenzoic acid decarboxylase has industrial applications for the decarboxylation of ring mounted carboxyls, specifically the decarboxylation of 2,3-dihydroxybenzoic acid to catechol. This invention relates to the isolation of a nucleic acid sequence from Aspergillus niger that encodes an enzyme that decarboxylates 2,3-dihydroxybenzoic acid. This invention further discloses the nucleic acid sequence, the protein sequence, vectors comprising the nucleic acid sequence, cells transformed with the nucleic acid sequence, and methods for the production of 2,3-dihydroxybenzoic acid decarboxylase.

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Santha, R., Savithri, H.S., Rao, N.A., and Vaidyanathan, C.S., "2,3-Dihydroxybenzoic Acid Decarboxylase from Aspergillus Niger," Eur. J. Biochem., 230, 1995, pp. 104-110.
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