Gene delivery vectors provided with a tissue tropism for...

Details Gene delivery vectors provided with a tissue tropism for... Gene delivery vectors provided with a tissue tropism for...

2005-08-16

2005-08-16

Chen, Shin-Lin (Department: 1632)

Chemistry: molecular biology and microbiology

Vector, per se

C435S455000, C424S093200, C424S093210, C536S023700, C536S023720

Reexamination Certificate

active

06929946

ABSTRACT:
A gene delivery vehicle having been provided with at least a tissue tropism for cells selected from the group of smooth muscle cells, endothelial cells, and/or liver cells. The tissue tropism is generally provided by a virus capsid, such as one comprising protein fragments from at least two different viruses, such as two different adenoviruses, including adenovirus of subgroup C or subgroup B (for example, adenovirus 16). The protein fragments can comprises a tissue tropism determining fragment of a fiber protein derived from a subgroup B adenovirus. Also, cells for producing such gene delivery vehicles and pharmaceutical compositions containing said gene delivery vehicles. Further, a method of delivering nucleic acid to cells such as smooth muscle cells and/or endothelial cells which involves administering to the cells an adenovirus capsid having proteins from at least two different adenoviruses and wherein at least a tissue tropism determining fragment of a fiber protein is derived from a subgroup B adenovirus. Particular construct are also disclosed.

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