Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1997-07-09
1999-10-26
Stanton, Brian R.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
4353201, 435440, 514 44, C12N 1500
Patent
active
059727071
ABSTRACT:
A gene delivery system is made of enzymatically degradable polymeric cation and nucleic acid (DNA or RNA) nanospheres optionally with a linking moiety or a targeting ligand attached to the surface. The delivery system can be made by a simple method of coacervation. Targeting ligands can be attached to the nanosphere directly or via a linking moiety. The linkage design allows the attachment of any molecule onto the nanosphere surface including antibodies, cell adhesion molecules, hormones and other cell-specific ligands.
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August Thomas
Leong Kam W.
Mao Hai-quan
Roy Krishnendu
Truong Vu L.
Clark Deborah J. R.
Stanton Brian R.
The Johns Hopkins University
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