Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2007-08-14
2007-08-14
Woitach, Joseph (Department: 1633)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C435S320100, C435S069100, C435S455000, C424S093200
Reexamination Certificate
active
11007315
ABSTRACT:
The present provides methods and compositions that enable effective delivery of nucleic acids to desired cells, including to a solid organ such as a mammalian heart. The methods and compositions enable effective gene transfer and subsequent expression to a majority of cells throughout a solid organ such as the heart. Methods and compositions of the invention preferably provide enhanced vascular permeability that enables increased gene transfer to targeted cells, but without significant degradation or injury to endothelial cell layers. Global delivery of nucleic acid to an intact heart has been achieved with as little as 2 minutes of intracoronary exposure to the administered nucleic acid.
REFERENCES:
patent: 4438029 (1984-03-01), Erickson et al.
patent: 5177060 (1993-01-01), Wei
patent: 5219746 (1993-06-01), Brinegar et al.
patent: 5240848 (1993-08-01), Keck et al.
patent: 5308622 (1994-05-01), Casscells et al.
patent: 5328470 (1994-07-01), Nabel et al.
patent: 5652225 (1997-07-01), Isner
patent: 5661133 (1997-08-01), Leiden et al.
patent: 5693622 (1997-12-01), Wolff et al.
patent: 5776427 (1998-07-01), Thorpe et al.
patent: 5797870 (1998-08-01), March et al.
patent: 5853694 (1998-12-01), Engberts et al.
patent: 5869230 (1999-02-01), Sukhatme
patent: 6007817 (1999-12-01), Epstein et al.
patent: 6013780 (2000-01-01), Neufeld et al.
patent: 6015556 (2000-01-01), Bagshave
patent: 6177403 (2001-01-01), Stedman
patent: 6214620 (2001-04-01), Johns et al.
patent: 6265387 (2001-07-01), Wolff et al.
patent: 6376471 (2002-04-01), Lawrence et al.
patent: 6855701 (2005-02-01), Lawrence et al.
patent: 2003/0195495 (2003-10-01), Ryan et al.
patent: 0-370989 (1989-11-01), None
patent: WO 93/00051 (1993-01-01), None
patent: WO 96/37196 (1996-11-01), None
Invitrogen life technologies. Calcium Phospahte Transfection Kit and Technical Resources Media Formulations.
Guzman et al.,Cir Res1993, 73:1202-1207.
Kass-Eisler,Proc Natl Acad Sci1993, 90:11498-11502.
Barr et al.,Gene Therapy1994, 1:51-58.
Muhlhauser et al.,Gene Therapy1996, 3:145-153.
Wang et al.,Transplation1996, 61:1726-1729.
Grossman et al.,Nat Genet1994, 6:335-341.
Kay et al.,Science1993, 262:117-119.
Raper et al.,Cel Transplation1993, 2:381-400.
Ferry et al.,Proc Natl Acad Sci USA1991, 88:8377-8391.
Lieber et al.,Proc Natl Acad Sci USA1995, 92:6210-6214.
Heikkilia et al.,Gene Ther1996, 3(1):21-27.
Mastrangelo et al.,Seminars In Oncologyvol. 23, 1996.
Anderson et al.,Nature, vol. 392, 25-30, 1998.
Verma et al.,Nature, vol. 389, 239-242, 1997.
Donahue J. Kevin
Lawrence, III John H.
Banner & Witcoff
Johns Hopkins University
Leavitt Maria
Woitach Joseph
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