Surgery – Means for introducing or removing material from body for... – Treating material introduced into body by contact with wound...
Patent
1995-05-19
1997-12-16
Buiz, Michael Powell
Surgery
Means for introducing or removing material from body for...
Treating material introduced into body by contact with wound...
4351721, 4352401, C12N 1500
Patent
active
056979010
ABSTRACT:
Direct gene transfer of genetic material into an external or internal target cell site ("microseeding"), in optional combination with a wound treatment chamber, are particularly effective as a way of obtaining long term expression of native or non-native polypeptides in a host. A wide variety of proteins and materials can be expressed, either for secretion into the general blood and lymphatic system, or to alter the properties of the protein, for example, to not express proteins eliciting an immune response. The use of the optional wound chamber system for gene transfer to skin target sites also allows non-invasive assessment of the success of transfer by assaying for the presence of the expressed protein in wound fluid, in contrast to the prior art use of invasive techniques, such as biopsies, in order to achieve the same assessment of early expression.
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Buiz Michael Powell
Eriksson Elof
Nguyen A. T.
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