Gene cluster for production of the enediyne antitumor...

Details Gene cluster for production of the enediyne antitumor... Gene cluster for production of the enediyne antitumor...

2006-09-19

2006-09-19

Nashed, Nashaat T. (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S252350, C435S320100, C536S023200, C536S023100, C536S023700

Reexamination Certificate

active

07109019

ABSTRACT:
This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced byStreptomyces globisporus). The pathway comprises a nonriobsomal peptide synthetase (NRPS). Methods are provided for the biosynthesis of enediynes, enediyne analogs and other biological molecules.

REFERENCES:
patent: 6733998 (2004-05-01), Thorson
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