Gene capable of enhancing S-adenosyl-L-methionine accumulation a

Details Gene capable of enhancing S-adenosyl-L-methionine accumulation a Gene capable of enhancing S-adenosyl-L-methionine accumulation a

1988-12-23

1992-03-31

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

4351723, 435193, 435224, 4352523, 435255, 4353201, 536 27, 535 60, 535 69, C12P 1304, C12N 1554, C12N 1581

Patent

active

051007860

ABSTRACT:
A gene which provides resistance to at least one methionine derivative and is capable of enhancing accumulation of S-adenosyl-L-methionine (SAM) in a cell, a hybrid plasmid having the same, a cell transformed with the above hybrid plasmid, and a process for producing SAM using the above cell. According to the present invention, SAM, which has various therapeutic effects, can be producing in a large amount at a low cost.

REFERENCES:
patent: 3962034 (1976-06-01), Tsuchida et al.
patent: 4546082 (1985-10-01), Kurjan et al.
Thomas et al., 1988, Mol. Cell. Biol. 8:5132, SAM2 encodes the 2nd Methionine S-Adenosyl.
Thomas et al., 1987, J. Biol. Chem. 262:16,704, SAM1, the Structural Gene of One of the S-Adenosylmethionine Synthetases in S, cerevisiae.
Shiomi et al., 1988, Cloning of a Gene for S-adenosylmethionine synthesis in S. cerevisiae. Appl. Microbiol. Bio. Tech. 29: 302-304.
Journal of Bacteriology, vol. 121, No. 1, pp. 267-271 (1975).

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